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Chemosensitivity

Volume II: In Vivo Models, Imaging, and Molecular Regulators. 'Methods in Molecular Medicine'. Auflage 2005.…
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A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Mod … weiterlesen
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Produktdetails

Titel: Chemosensitivity

ISBN: 1588295869
EAN: 9781588295866
Volume II: In Vivo Models, Imaging, and Molecular Regulators.
'Methods in Molecular Medicine'.
Auflage 2005.
Book.
Sprache: Englisch.
Herausgegeben von Rosalyn D. Blumenthal
Humana Press

14. Februar 2005 - gebunden - 472 Seiten

Beschreibung

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor. Chemosensitivity testing is an ex vivo means of determining or enhancing the cytotoxic and/or cytostatic, or apoptosis-inducing effects of anticancer drugs. In Chemosensitivity, leading researchers and physicians working in academia and biotech companies describe their best laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains today's best protocols for classifying tumors into response categories and for customizing therapy to individuals. These techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. Highlights include genomic and proteomic approaches to assess chemosensivity, in vivo imaging approaches to assess early response to therapy, and methods to statistically analyze data from in vivo therapy. The protocols follow the successful Methods in Molecular Medicine series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The authors also provide guidance on how best to analyze the data derived from the protocols. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor. Cutting-edge and highly practical, the two volumes of Chemosensitivity provide a comprehensive collection of readily reproducible techniques for the in vitro and in vivo screening of new agents and a set of proven approaches to understand mechanistically why certain cancer cell lines (in vitro) of tumors (in vivo) are more or less sensitive to a particular agent.

Inhaltsverzeichnis

Part I. Measurements of DNA Damage, Cell Death, and Regulators of Cytotoxicity

In Vitro Micronucleus Technique to Predict Chemosensitivity
Michael Fenech

Cell Cycle and Drug Sensitivity
Aslamuzzaman Kazi and Q. Ping Dou

TUNEL Assay as a Measure of Chemotherapy-Induced Apoptosis
Robert Wieder

Apoptosis Assessment by the DNA Diffusion Assay
Narendra P. Singh

PARP Cleavage and Caspase Activity to Assess Chemosensitivity
Alok C. Bharti, Yasunari Takada, and Bharat B. Aggarwal

Diphenylamine Assay of DNA Fragmentation for Chemosensitivity Testing
Cicek Gercel-Taylor

Immunodetecting Members of the Bcl-2 Family of Proteins
Richard B. Lock and Kathleen M. Murphy

Correlation of Telomerase Activity and Telomere Length to Chemosensitivity
Yasuhiko Kiyozuka

Application of Silicon Sensor Technologies to Tumor Tissue In Vitro: Detection of Metabolic Correlates of Chemosensitivity
Pedro Mestres-Ventura, Andrea Morguet, Anette Schofer, Michael Laue, and Werner Schmidt

Overview of Tumor Cell Chemoresistance Mechanisms
Laura Gatti and Franco Zunino

Flow Cytometric Monitoring of Fluorescent Drug Retention and Efflux
Awtar Krishan and Ronald M. Hamelik

Flow Cytometric Measurement of Functional and Phenotypic P-Glycoprotein
Monica Pallis and Emma Das-Gupta

Measurement of Ceramide and Sphingolipid Metabolism in Tumors: Potential Modulation of Chemosensitivity
David E. Modrak

Part II. Genomics, Proteomics, and Chemosensitivity

Gene Expression Profiling to Characterize Anticancer Drug Sensitivity
James K. Breaux and Gerrit Los

Identifying Genes Related to Chemosensitivity Using Support Vector Machine
Lei Bao

Genetic Manipulation of Yeast to Identify Genes Involved in Regulation of Chemosensitivity
Giovanni L. Beretta and Paola Perego

Real-Time RT-PCR (Taqman®) of Tumor mRNA to Predict Sensitivity of Specimens to 5-Fluorouracil
Tetsuro Kubota

Use of Proteomics to Study Chemosensitivity
Julia Poland, Silke Wandschneider, Andrea Urbani, Sergio Bernardini, Giorgio Federici, and Pranav Sinha

Part III. In Vivo Animal Modeling of Chemosensitivity

Clinically Relevant Metastatic Breast Cancer Models to Study Chemosensitivity
Lee Su Kim and Janet E. Price

Orthotopic Metastatic (MetaMouse®) Models for Discovery and Development of Novel Chemotherapy
Robert M. Hoffman

Preclinical Testing of Antileukemic Drugs Using an In Vivo Model of Systemic Disease
Richard B. Lock, Natalia L. Liem, and Rachael A. Papa

Assessing Growth and Response to Therapy in Murine Tumor Models
C. Patrick Reynolds, Bee-Chun Sun, Yves A. DeClerck, and Rex A. Moats

Evaluation of Chemosensitivity of Micrometastatses with Green Fluorescent Protein Gene-Tagged Tumor Models in Mice
Hayao Nakanishi, Seiji Ito, Yoshinari Mochizuki, and Masae Tatematsu

99mTc-Annexin A5 Uptake and Imaging to Monitor Chemosensitivity
Tarik Z. Belhocine and Francis G. Blankenberg

Magnetic Resonance Imaging of Tumor Response to Chemotherapy
Richard Mazurchuk and Joseph A. Spernyak

Metabolic Monitoring of Chemosensitivity with 18FDG PET
Guy Jerusalem and Tarik Z. Belhocine

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