Titel: Molecular Approaches to Malaria
Herausgegeben von Irwin W. Sherman
September 2005 - gebunden - 542 Seiten
Molecular Approaches to Malaria provides an overview of the rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. An important resource for molecular biologists, biochemists, cell biologists, chemists, pathologists, parasitologists, entomologists, and immunologists, Molecular Approaches to Malaria is a single reference source that will serve likewise to update teachers, investigators, and public health officials on the status of malaria research. Written by an international group of bench scientists who are leaders in the field, the book opens with a clearly written introduction to Plasmodium molecular biology, followed by several chapters on its genetics and evolution. The remaining five sections examine the intricate host-parasite relationship through comprehensive coverage of invasion and gamete formation; growth and metabolism; immune invasion; protection mechanisms; and the malaria vector.
Table of Contents Introduction 1. The Life of Plasmodium: an Overview, Irwin W. Sherman 2. PlasmoDB: the Plasmodium Genome Resource, Patricia L. Whetzel, Shailesh V. Date, Kobby Essien, Martin J. Fraunholz, Bindu Gajria, Gregory R. Grant, John Iodice, Jessical C. Kissinger, Philip T. Labo, Arthur J. Milgram, Christian J. Stoeckert, Jr., and David Roos 3. Making a Home for Plasmodium Post-Genomics: Ultrastructural Organization of the Blood Stages, Lawrence H. Bannister, Gabriele Margos, and John M. Hopkins 4. Genetic Manipulation of Plasmodium falciparum, Alan F. Cowman and Brendan S. Crabb 5. The Transcriptome of the Malaria Parasite Plasmodium falciparum, Karine Le Roch and Elizabeth Winzeler 6. The Plasmodium Proteome, Jeffrey R. Johnson and John R. Yates III 7. Evolutionary History and Population Genetics of Human Malaria Parasites, Martine Zilversmit and Daniel L. Hartl Invasion and Gamete Formation 8. A Mechanistic Approach to Merozoite Invasion of Red Blood Cells: Merozoite Biogenesis, Rupture, and Invasion of Erythrocytes, Mary R. Galinski, Anton R. Dluzewski, and John W. Barnwell 9. The Sporozoite, R. E. Sinden and K. Matuschewski 10. Gametocytes and Gametes, Pietro Alano and Oliver Billker Growth and Metabolism 11. Molecular Approaches to Malaria: Glycolysis in Asexual-Stage Parasites, Charles J. Woodrow and Sanjeev Krishna 12. The Mitochondrion, Akhil B. Vaidya 13. Trafficking and the Tubulovesicular Membrane Network, Kasturi Haldar, Narla Mohandas, Souvik Bhattacharjee, Travis Harrison, N. Luisa Hiller, Konstantinos Liolios, Sean Murphy, Pamela Tamez, and Christiaan van Ooij 14. The Apicoplast, Stuart A. Ralph 15. Protein Kinases Regulating Plasmodium Proliferation and Development, Christian Doerig 16. Proteases and Hemoglobin Degradation, Philip J. Rosenthal 17. Plasmodium Lipids: Metabolism and Function, Henri J. Vial and Choukri Ben Mamoun 18. Plasmodium Ribosomes and Opportunities for Drug Intervention, Indu Sharma and Thomas F.. McCutchan 19. Oxidative Stress and Antioxidant Defense in Malarial Parasites, Katja Becker, Sasa Koncarevic, and Nicolas H. Hunt 20. New Permeation Pathways, Serge L. Thomas and Stephanie Egee Immune Evasion 21. Molecular Aspects of Antigenic Variation in Plasmodium falciparum, Paul Horrocks, Susan A. Kyes, Peter C. Bull, and Kirk W. Deitsch 22. Rosetting, J. Alexandra Rowe Protection 23. Mechanisms of Antimalarial Drug Action and Resistance, Anne-Catrin Uhlemann, Yongyuth Ythavong, and David A. Fidock 24. Host Genetic Factors in Resistance and Susceptibility to Malaria, Dominic P. Kwiatkowski and Gaia Luoni 25. Progress in Development of a Vaccine To Aid Malaria Control, Vasee S. Moorthy and Filip Dubovsky Vector 26. The Anopheles gambiae Genome, Frank H. Collins and Catherine A. Hill 27. The Transcriptome of Human Malaria Vectors, Osvaldo Marinotti and Anthony A. James