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Molecular Cytogenetics

Protocols and Applications. 'Methods in Molecular Biology'. Auflage 2003. Book. Sprache: Englisch.
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The new techniques of molecular cytogenetics, mainly fluorescence in situ hybridization (FISH) of DNA probes to metaphase chromosomes or interphase nuclei, have been developed in the past two decades. Many FISH techniques have been implemented for di … weiterlesen
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Molecular Cytogenetics als Buch

Produktdetails

Titel: Molecular Cytogenetics

ISBN: 1588290069
EAN: 9781588290069
Protocols and Applications.
'Methods in Molecular Biology'.
Auflage 2003.
Book.
Sprache: Englisch.
Herausgegeben von Yao-Shan Fan
Humana Press

13. September 2002 - gebunden - 428 Seiten

Beschreibung

The new techniques of molecular cytogenetics, mainly fluorescence in situ hybridization (FISH) of DNA probes to metaphase chromosomes or interphase nuclei, have been developed in the past two decades. Many FISH techniques have been implemented for diagnostic services, whereas some others are mainly used for investigational purposes. Several hundreds of FISH probes and hybridization kits are now commercially available, and the list is growing rapidly. FISH has been widely used as a powerful diagnostic tool in many areas of medicine including pediatrics, medical genetics, maternal-fetal medicine, reproductive medicine, pathology, hematology, and oncology. Frequently, a physician may be puzzled by the variety of FISH techniques and wonder what test to order. It is not uncommon that a sample is referred to a laboratory for FISH without indicating a specific test. On the other hand, a cytogeneticist or a technologist in a laboratory needs, from case to case, to determine which procedure to perform and which probe to use for an informative result. To obtain the best results, one must use the right DNA probes and have reliable protocols and measures of quality assurance in place. Also, one must have sufficient knowledge in both traditional and molecular cytogenetics, as well as the particular areas of medicine for which the test is used in order to appropriately interpret the FISH results, and to correlate them with clinical diagnosis, treatment, and prognosis.

Inhaltsverzeichnis

Part I. Basic Concepts and Techniques

Molecular Cytogenetics in Medicine: An Overview
Yao-Shan Fan

Labeling Fluorescence In Situ Hybridization Probes for Genomic Targets
Larry E. Morrison, Ramesh Ramakrishnan, Teresa M. Ruffalo, and Kim A. Wilber

Labeling Fluorescence In Situ Hybridization Probes for RNA Targets
Ramesh Ramakrishnan and Larry E. Morrison

Basic FISH Techniques and Troubleshooting
Sue Van Stedum and Walter King

Part II. Evolving Techniques and Applications

Chromosome Microdissection
Xin-Yuan Guan

Primed In Situ Labeling
Jørn Koch

Spectral Karyotyping
Jane Bayani and Jeremy A. Squire

Multicolor FISH
Syed M. Jalal and Mark E. Law

Characterization of Constitutional Chromosome Abnormalities by Comparative Genomic Hybridization
Brynn Levy and Kurt Hirschhorn

Color Banding
Vicki L. Hopwood, Christi J. Hada, and Armand B. Glassman

Multicolor Fiber FISH
Jaennelle Kraan, Anne R. M. von Bergh, Karin Kleiverda, Jan-Willem Vaandrager, Ekaterina S. Jordanova, Anton K. Raap, Philip M. Kluin, and Ed Schuuring

Multi-Telomere FISH
Samantha J. L. Knight and Jonathan Flint

Fluorescence Genotyping for Screening Cryptic Telomeric Rearrangements
Laurence Colleaux, Solange Heuertz, Florence Molinari, and Marlene Rio

Microarray CGH, Ben Beheshti, Paul C. Park, Ilan Braude, and Jeremy A. Squire

Part III. Special Applications in Chromosomal Disorders

Molecular Approaches for Delineating Marker Chromosomes
Michael D. Graf and Stuart Schwartz

Interphase FISH for Prenatal Diagnosis of Common Aneuploidies
Baruch Feldman, Ayala Aviram-Goldring, and Mark I. Evans

Prenatal Diagnosis of Chromosomal Abnormalities Using Maternal Blood, Farideh Z. Bischoff, Dianne X. Dang, Dorothy E. Lewis, and Joe LeighSimpson

Preimplantation FISH Diagnosis of Aneuploidies
Yury Verlinsky, Jeanine Cieslak, and Anver Kuliev

Microdeletion Syndromes: Characteristics and Diagnosis
Stuart Schwartz and Michael D. Graf

Molecular Detection of Uniparental Disomy
Wendy P. Robinson

Molecular Cytogenetics in Reproductive Pathology
Hélène Bruyère, Evica Rajcan-Separovic, and Dagmar K. Kalousek

Part IV. Special Applications in Oncology

Interphase FISH Studies of Chronic Myeloid Leukemia, Gordon W. Dewald

Chromogenic In Situ Hybridization and FISH in Pathology
Bae-Li Hsi, Sheng Xiao, and Jonathan A. Fletcher

FISH Detection of HER2 Amplification in Breast Cancer
Rosemary E. Mueller and Frances P. O'Malley

Comparative Genomic Hybridization in Cancer Investigations
Marjan M. Weiss, Mario A. J. A. Hermsen, Gerrit A. Meijer, and Paul J. van Diest

Simultaneous Fluorescence Immunophenotyping and FISH on Tumor Cells
Yanming Zhang and Brigitte Schlegelberger

BAC Resource for Molecular Cytogenetics
Xiao-Ning Chen and Julie R. Korenberg

Index

Pressestimmen

"Dr. Fan has done a marvelous job of putting together a collection of laboratory protocols and review articles of different FISH technologies...Molecular Cytogenetics: Protocols and Applications is packed with information on cutting-edge FISH technologies and their applications, limitations, and pitfalls, along with detailed laboratory protocols. I would certainly recommend that this book be included in the libraries of cytogeneticists and cytogenetic laboratories" - Am. J. Hum. Gent.
"Dr. Fan has done a marvelous job of putting together a collection of laboratory protocols and review articles of different FISH technologies. The authors of the different chapters not only gave detailed, easy-to-follow protocols, but also provided their first-hand experiences of troubleshooting. Molecular Cytogenetics: Protocols and Applications is packed with information on cutting-edge FISH technologies and their applications, limitations, and pitfalls, along with detailed laboratory protocols. I would certainly recommend that this book be included in the libraries of cytogeneticists and cytogenetic laboratories." -The American Society of Human Genetics
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