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Molecular Modeling and Prediction of Bioactivity

Softcover reprint of the original 1st ed. 2000. Book. Sprache: Englisch.
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Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane … weiterlesen
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Molecular Modeling and Prediction of Bioactivity als Buch

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Titel: Molecular Modeling and Prediction of Bioactivity

ISBN: 0306462176
EAN: 9780306462177
Softcover reprint of the original 1st ed. 2000.
Book.
Sprache: Englisch.
Herausgegeben von Klaus Gundertofte, Fleming Steen Jørgensen
Springer US

31. Januar 2000 - kartoniert - 520 Seiten

Beschreibung

Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane penetration. For any set of compounds, these relationships are by necessity complicated, particularly when the properties are of biological nature. To investigate and utilize such complicated relationships, henceforth abbreviated SAR for structure-activity relationships, and QSAR for quantitative SAR, we need a description of the variation in chemical structure of relevant compounds and biological targets, good measures of the biological properties, and, of course, an ability to synthesize compounds of interest. In addition, we need reasonable ways to construct and express the relationships, i. e. , mathematical or other models, as well as ways to select the compounds to be investigated so that the resulting QSAR indeed is informative and useful for the stated purposes. In the present context, these purposes typically are the conceptual understanding of the SAR, and the ability to propose new compounds with improved property profiles. Here we discuss the two latter parts of the SARlQSAR problem, i. e. , reasonable ways to model the relationships, and how to select compounds to make the models as "good" as possible. The second is often called the problem of statistical experimental design, which in the present context we call statistical molecular design, SMD. 1.

Inhaltsverzeichnis


Section I: Overview. .
Section II: New Developments and Applications of Multivariate QSAR.
Section III: The Future of 3D-QSAR.
Section IV: Prediction of Ligand-Protein Binding.
Section VI:Affinity and Efficacy Models of G-Protein Coupled Receptors.
Section VII: New Methods in Drug Discovery
Section VIII: Modeling of Membrane Penetration.
Section IX: Poster Presentations. Poster
Session I: New Developments and Applications of Multivariate QSAR. Poster
Session II: The Future of 3D-QSAR. Poster
Session III: Prediction of Ligand-Protein Binding. Poster
Session IV: Computational Aspects of Molecular Diversity and Combinatorial Libraries. Poster
Session V: Affinity and Efficacy Models of G-Protein Coupled Receptors. Poster
Session VI: New Methods in Drug Discovery. Poster
Session VII: Modelling of Membrane Penetration. Author Index. Subject Index.
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