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Molecular Neurosurgery with Targeted Toxins

Auflage 2005. Book. Sprache: Englisch.
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State-of-the-Art Review of Molecular Neurosurgery Techniques Using Targeted Cytotoxins
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Titel: Molecular Neurosurgery with Targeted Toxins

ISBN: 1588291995
EAN: 9781588291998
Auflage 2005.
Book.
Sprache: Englisch.
Herausgegeben von Douglas A. Lappi, Ronald G. Wiley
Humana Press

22. März 2005 - gebunden - 328 Seiten

Beschreibung

The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.

Inhaltsverzeichnis

Introduction to Molecular Neurosurgery
Ronald G. Wiley and Douglas A. Lappi

Ribosome-Inactivating Proteins
Fiorenzo Stirpe

Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin
Jerene J. Waite

Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin: A Tool to Assess the Consequences of Cortical Cholinergic Dysfunction in Alzheimer¿s Disease
Reinhard Schliebs

192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System
Martin Sarter and John P. Bruno

Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin
Rosalind M. Ridley and Harry F. Baker

Cortical Cholinergic Deafferentation Induces Ab Deposition: Toward a Physiological Animal Model of Alzheimer's Disease
Thomas G. Beach, D. G. Walker, P. E. Potter, L. I. Sue, S. Scott, K. J. Layne, A. J. Newell, P. K. Rauschkolb, M. E. Poston, S. D. Webster, R. A. Durham, M. R. Emmerling, K. Sawada, W. G. Honer, A. Fisher, and A. E. Roher

Chemical Dissection of Brain Glucoregulatory Circuitry
Sue Ritter, Thu T. Dinh, Kishor Bugarith, and Dawna M. Salter

Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin
Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer

Saporin Conjugates and Pain
Ronald G. Wiley and Douglas A. Lappi

The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness
Carlos Blanco-Centurion, Dmitry Gerashchenko, Eric Murillo-Rodriguez, Frank Desarnaud, and Priyattam J. Shiromani

Isolectin B4-Mediated Cytotoxic Targeting of Sensory Neurons
Lucy Vulchanova and Christopher N. Honda

B Fragment of Cholera ToxinConjugated to Saporin
Peter T. Ohara, Kanwarjit Kelley, and Luc Jasmin

Index

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"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal
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