Titel: New Frontiers in Asymmetric Catalysis
Herausgegeben von Koichi Mikami, Mark Lautens
JOHN WILEY & SONS INC
Mai 2007 - gebunden - 418 Seiten
A compilation of recent advances and applications in asymmetric catalysis
The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers:
* "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation)
* Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis
* Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis
* Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts
The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.
Introductory Preface (K. Mikami and M. Lautens).
Chapter 1. Ligand Design for Catalytic Asymmetric Reduction (T. Ohkuma, M. Kitamura, and R. Noyori).
Chapter 2. Ligand Design for Oxidation (T. Yamada)
Chapter 3. Ligand Design for C-C Bond Formation (R. Shintani and T. Hayashi).
Chapter 4. Activation of small molecules (C=O, HCN, RN=C, and CO2) (K. Nozaki).
Chapter 5. Asymmetric Synthesis Based on the Catalytic Activation of C-H and C-C Bonds (C.-J. Li).
Chapter 6. Recent Progress in the Metathesis Reaction M. Mori).
Chapter 7. Activation and De-activation (K. Mikami and K. Aikawa).
Chapter 8. Auto-Catalysis (K. Soai).
Chapter 9. Recent Advances in Catalytic Asymmetric Desymmetrization Reactions (T. Rovis).
Chapter 10. History & Perspective of Chiral Organic Catalysts (G.Lelais and D.W.C.Macmillan).
Chapter 11. Chiral Acid Catalysts (K. Ishihara and H. Yamamoto).
Chapter 12. Recent Advances in Chiral Base Catalysts (M. Shibasaki and Motomu Kanai).
Future perspective (K. Mikami and M. Lautens).
Koichi Mikami is Professor in the Department of Applied Chemistry at the Tokyo Institute of Technology.
Mark Lautens is AstraZeneca Professor of Organic Synthesis and Merck Frosst/NSERC Industrial Research Chair in the Davenport Laboratories at the University of Toronto.
"...this book has definite value and is strongly recommended for inclusion in both academic and industrial research libraries." (Angewandte Chemie, Intern. Edition, November 2007)