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Molecular Toxicology

Second. Sprache: Englisch.
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The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxin… weiterlesen
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Molecular Toxicology als Buch

Produktdetails

Titel: Molecular Toxicology
Autor/en: P. David Josephy, Bengt Mannervik

ISBN: 0195176200
EAN: 9780195176209
Second.
Sprache: Englisch.
OXFORD UNIV PR

Februar 2006 - gebunden - 589 Seiten

Beschreibung

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at
the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,
among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,
as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Inhaltsverzeichnis

Act One: Toxicity at the Cellular Level; 1. Toxicology of oxygen; 2. Covalent Binding of Xenobiotics to DNA and Protein; 3. DNA Repair; 4. Chemical Mutagenesis; 5. Oncogenes, tumor suppressor genes, and mutations in cancer cells; TUMORS; 6. Toxicity, survival, and target theory; Act Two: Enzymology of Biotransformation; 7. Cytochrome P450 - Chemical and Biochemical Aspects; 8. P450: Biological aspects; regulation; genetics; 9. Biochemistry of glutathione; 10. Glutathione transferases; 11. Glutathione and glutathione transferases: Toxicological and pharmacological aspects; 12. Glucuronidation; 13. Arylamine N-Acetyltransferase; 14. Sulfotransferase; Act Three: Molecular Principles Applied to Specific Toxicants; 15. Alkylating agents and "mustards"; 16. Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia; 17. Aromatic amines and related toxic compounds; 18. Polycyclic aromatic hydrocarbon carcinogens; 19. Acetaminophen

Portrait

P. David Josephy is Professor of Molecular and Cellular Biology at the University of Guelph. Bengt Mannervik is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.
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