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The Adrenergic Receptors

In the 21st Century. 'The Receptors'. Auflage 2006. Book. Sprache: Englisch.
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An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range … weiterlesen
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Titel: The Adrenergic Receptors

ISBN: 1588294234
EAN: 9781588294234
In the 21st Century.
'The Receptors'.
Auflage 2006.
Book.
Sprache: Englisch.
Herausgegeben von Dianne M. Perez
Humana Press

1. September 2005 - gebunden - 424 Seiten

Beschreibung

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

Inhaltsverzeichnis

Part I: Historical Perspectives

Adrenergic Receptors: Historical Perspectives From the 20th Century
David B. Bylund

Part II: Structure-Function

Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna, and Robert M. Graham

New Signal Transduction Paradigms
Kenneth P. Minneman

Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis García-Cazarin, and Steven R. Post

Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel

Part III: Imaging Adrenergic Receptors and Their Function

Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly

Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez

Part IV: Genetically Altered Mouse Models

The a1-Adrenergic Receptors: Lessons From Knockout
Paul C. Simpson

The a2-Adrenergic Receptors: Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird

The b-Adrenergic Receptors: Lessons From Knockouts
Yang Xiang and Brian Kobilka

Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman

Adrenergic Receptor Signaling Components in Gene Therapy
Andrea D. Eckhart and Walter J. Koch

Part V: Pharmacogenomics

Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
Stephen B. Liggett

Microarray Analysis of Novel Adrenergic Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez

Part VI: Summary and Future Endeavors

Summary and Future Endeavors
Dianne M. Perez

Index

Pressestimmen

From the reviews:
"...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry
"Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. ... many MDs, biologists, and pharmacologists will find the book ... appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)
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