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Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

'Handbook of Experimental Pharmacology'. Auflage 2004. Book. Sprache: Englisch.
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Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic… weiterlesen
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Titel: Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics
Autor/en: Yoshihiro Kawaoka

ISBN: 3540406611
EAN: 9783540406617
'Handbook of Experimental Pharmacology'.
Auflage 2004.
Book.
Sprache: Englisch.
Herausgegeben von Yoshihiro Kawaoka
Springer Berlin Heidelberg

7. Mai 2004 - gebunden - 364 Seiten

Beschreibung

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

Inhaltsverzeichnis

Introduction.- Reverse genetics of mononegavirales.- Reverse systems for the generation of segmented negative-sense RNA viruses entirely from cloned cDNA.- Transcription and replication of non-segmented negative strand RNA viruses.- Orthomyxovirus replication, transcription, and polyadenylation.- Escaping from the cell: assembly and budding of negative-strand RNA viruses.- Accessory genes of the paramyxoviridae, a large family of nonsegmented negative strand RNA viruses, as a focus of active investigation by reverse genetics.- Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses.- Towards multivalent vaccines and therapeutic viruses.- Influenza vaccines generated by reverse genetics.- Subject index
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