Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Proceedings of a NATO ASI held in Çesme (Izmir), Turkey, August 27-September 7, 1989.

Cytochrome P450-Dependent Monooxygenase: An Overview. - The Flavin-Containing Monooxygenase (EC 1. 14. 13. 8). - Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical, Physical, Immunological and Biocatalytic Properties. - Primary Structures and Regulation of Cytochrome P450 Isozymes 2 (IIB) and 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung. - Insect Cytochrome P450. - I. Membrane Topology of Cytochromes P450: Elements and Measurement by Spectroscopic Techniques. - II. Membrane Topology of Cytochromes P450: Oligomers and Cooperativity. - NADPH-Dependent Cytochrome P450 Reductase A. Y. H. Lu. - Essential Features of NADH Dependent Cytochrome b5 Reductase and Cytochrome b5 of Liver and Lung Microsomes. - Electron Transfer from Cytochrome b5 to Cytochrome P450. - Functional Aspects of Protein-Protein Interactions of Cytochrome P450, Cytochrome b5 and Cytochrome P450 Reductase. - Posttranslational Modification by Phosphorylation: Control of Cytochrome P450 and Associated Enzymes. - Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450. - Ontogenesis of Liver Cytochromes P450. - Mechanism of Steroid Hormome Action A. Berkenstam. - Xenobiotic Regulation of Cytochrome P450 Gene Expression. - Prostanoid Metabolism and Biologically Active Product Formation. - Role of Cytochrome P450 in the Anabolism and Catabolism of Endobiotics. - Interactions of Estrogenic Pesticides with Cytochrome P450. - Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates. - Mechanism of Metabolic Activation of Nitroimidozoles. - Benzene Metabolism R. Snyder. - Mechanisms of Benzene Toxicity. - Hematotoxicity, Leukemogenecity and Carcinogenecity of Chronic Exposure to Benzene. - Epoxide Hydrolase Isoenzymes and Their Individual Contribution to the Control of Toxic Metabolites. - Role of the Weil-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites. - Characterisation and Regulation of UDP-Glucuronosyltransferases. - Molecular Cloning, Expression and Genetic Deficiencies of UDP-Glucuronosyltransferases. - Contributors.