Mechanism of Muscular Contraction

This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in 1954. An amazing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation. Some background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. Controversies in the muscle field are discussed along with some missed opportunities and false trails.

The pathway to ATP and the high energy phosphate bond will be discussed, as well as the discovery of myosin, contraction coupling and the emergence of cell and molecular biology in the muscle field. Numerous figures from original papers are also included for readers to see the data that led to important conclusions.

This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

Setting the Stage: Myosin, Actin, Actomyosin and ATP. - Birth of the Sliding Filament Model of Muscular Contraction: Proposal. - Glory Days: Establishment of the Sliding Filament Model of Muscular Contraction in the 1950s and 1960s. - Excitation-Contraction Coupling and the Role of Calcium in Contraction and Relaxation in the 1950s and 1960s. - Mechanics and Energetics of Muscular Contraction: Before Sliding Filaments and into the Modern Era. - 1972 Cold Spring Harbor Symposia On Quantitative Biology: The Mechanism of Muscle Contraction. Problem Solved? ? . - Endosarcomeric and Exosarcomeric Cytoskeleton: Emergence of Cell and Molecular Biology in the Muscle Field. - Excitation-contraction Coupling and Regulation of Contraction in Skeletal Muscle: The Modern Synthesis. - Molecular Mechanism of Force Production: From the Difficult 1980s to the Supercharged 1990s and Beyond. - Index.