Chemical Synthesis of Nucleoside Analogues examines the application of synthetic methodologies to the preparation of compounds of biological interest, including the synthesis of nucleic acids on pre-existing nucleic acid templates, assembling RNA, or DNA. This comprehensive compendium culls expert contributions that highlight the structural components of nucleosides (supported by spectral data) and their modification as well as the synthetic strategies based on chemical approaches. The text serves undergraduate students, specialists, and researchers, allowing access to a variety of compounds without forgetting the biological importance of the target compounds.
Inhaltsverzeichnis
Contributors ix
Foreword xiii
Preface xv
1 Biocatalytic Methodologies for Selective Modified Nucleosides 1
Miguel Ferrero, Susana Fern andez, and Vicente Gotor
2 Nucleosides Modified at the Base Moiety 49
O. Sari, V. Roy, and L. A. Agrofoglio
3 Chemical Synthesis of Acyclic Nucleosides 103
Hai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu
4 Phosphonated Nucleoside Analogues 163
Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio
5 Chemical Syntheses of Nucleoside Triphosphates 209
Lina Weinschenk and Chris Meier
6 Mononucleotide Prodrug Synthetic Strategies 229
Suzanne Peyrottes and Christian P erigaud
7 Synthesis of C-Nucleosides 263
Omar Boutureira, M. Isabel Matheu, Yolanda D ý az, and Sergio Castill on
8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317
Maurice Okello and Vasu Nair
9 Synthesis of Conformationally Constrained Nucleoside Analogues 345
Esma Maougal, Jean-Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton
10 Synthesis of 3-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427
Mar ý a-Jos e Camarasa, Sonsoles Vel azquez, Ana San-F elix, and Mar ý a-Jes us P erez-P erez
11 l-Nucleosides 473
Daniela Perrone and Massimo L. Capobianco
12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535
E. Leclerc
13 Uncommon Three-, Four-, and Six-Membered Nucleosides 605
E. Groaz and P. Herdewijn
14 Recent Advances in Synthesis and Biological Activity of 4-Thionucleosides 655
Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong
15 Recent Advances in the Chemical Synthesis of Aza-Nucleosides 699
Tom as Tejero, Ignacio Delso, and Pedro Merino
16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727
D. D'Alonzo and A. Guaragna
17 Isoxazolidinyl Nucleosides 781
Ugo Chiacchio, Antonino Corsaro, Salvatore Giofr`e, and Giovanni Romeo
18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819
Apurba Datta
19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847
Pedro Merino and Rosa Matute
Index 881
