This book presents and demonstrates a coarse-grained model of DNA, simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - it represents the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Inhaltsverzeichnis
A Novel DNA Model. - Methods. - Finite Size Effects. - Structural and Mechanical Properties of Model DNA. - Thermodynamic Properties of Model DNA. - Modelling DNA Tweezers. - Modelling a DNA Walker.
