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Liposomes: A Practical Approach als Buch

Liposomes: A Practical Approach

Second. Sprache: Englisch.
Buch (kartoniert)
Since the first edition of "Liposomes - A Practical Approach" was published in 1990, Liposome technology has become a highly successful and rapidly developing area of preclinical and clinical research. During the 90's, a number of liposome-based drug... weiterlesen


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Liposomes: A Practical Approach als Buch


Titel: Liposomes: A Practical Approach
Autor/en: Al P. Williams

ISBN: 0199636540
EAN: 9780199636549
Sprache: Englisch.
Herausgegeben von Vladimir Torchillin

Januar 2003 - kartoniert - 424 Seiten


Since the first edition of "Liposomes - A Practical Approach" was published in 1990, Liposome technology has become a highly successful and rapidly developing area of preclinical and clinical research. During the 90's, a number of liposome-based drugs reached the market in the U.S. and Europe
and several new aspects of liposome research have been discovered. As a consequence there has been an explosion of new procedures and techniques in the field. Reflecting both the significant changes in the field and the new discoveries, this new edition of Liposomes contains a combination of
chapters from the 1st edition which have been significantly updated, and several new chapters.
Each chapter is an outstanding contribution from leading experts in the field, and the book as a whole encompasses all key areas of liposome technology. The first half of the book addresses a number of essential experimental protocols such as the preparation, characterization, and storage of
liposomes. Also included are methods for drug encapsulation into liposomes, modification of the liposomal surface to control drug behaviour in biological environments, long-circulating liposomes and the use of cationic liposomes as transfection vectors. The second half of the book discusses specific
areas of liposome research and application, such as pH-sensitive liposomes, liposomes for diagnostic imaging, liposomal DNA vaccines, isothermic titration calorimetry of liposomes and vesicular phospholipids gels.
This new edition of Liposomes is an essential tool for all experienced liposomologists and the perfect introduction for researchers new to the field.


1. PREPARATION OF LIPOSOMES ; 2. Characterization of Liposomes ; 3. Physical Methods of Study: Differential Scanning of Calorimetry ; 4. Fluorescence methods in liposome research ; 5. Stability, storage and sterilization of liposomes ; 6. Encapsulation of weakly-basic drugs, antisense oligonucleotides and plasmid DNA within large unilamellar vesicles for drug delivery applications ; 7. Surface modifications of liposomes ; 8. Long-circulating sterically protected liposomes ; 9. Liposomes in biological systems ; 10. Cationic liposomes in gene delivery ; 1. PH-SENSITIVE LIPOSOMES ; 2. Radiolabeled liposomes for imaging and biodistribution ; 3. Isothermic Titration Calorimetry (ITC) ; 4. Vesicular phospholipid gels ; 5. Liposome-based DNA vaccines: Procedures for entrapment


Vladimir P. Torchilin is Professor and Chairman at the Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, He gained a Ph.D.and D.Sc. in Polymer Chemistry and Chemistry of Physiologically Active Compounds, and is now a professor of Pharmaceutical Sciences. He has published over 300 papers, reviews and book chapters, 8 books and special journal issues (as author and editor). He is currently a member of the American Chemical Society,
Controlled Release Society, AAPS, International Liposome Society and acts as a review editor for the Journal of Controlled Release, Associate Editor for Journal of Drug targeting, and is on the editorial boards of many other journal including Bioconjugate Chemistry and Advanced Drug Delivery Reviews.He
was awarded the Lenin Prize of the USSR in Science and Technology, 1982; Member, Russian Academy of Biotechnology, 1992, and is a fellow of the American Institute for Medical and Biological Engineering, 2002.

Volkmar Weissig is an Assistant Professor of Pharmaceutics, Northeastern University, Bouve College of Health Sciences, Department of Pharmaceutical Sciences. He gained a Ph.D. in Chemistry and Sc.D. in Biochemistry and Pharmaceutical Biotechnology. Asst. He has published over 40 papers, reviews and book chapters and over 70 abstracts. He is a member of the Controlled Release Society, the International Liposome Society, the Mitochondria Research Society and the Rho Chi Honour

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