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Molecular Diagnostics

For the Clinical Laboratorian. Sprache: Englisch.
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This updated and expanded tutorial guide to molecular diagnostic techniques takes advantage of many new molecular technologies to include both improved traditional methods and totally new methods, some not yet in routine use. The authors offer cuttin … weiterlesen
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Produktdetails

Titel: Molecular Diagnostics
Autor/en: William B. Coleman

ISBN: 1588293564
EAN: 9781588293565
For the Clinical Laboratorian.
Sprache: Englisch.
Springer, Berlin

16. April 2012 - gebunden - 567 Seiten

Beschreibung

In 1994 I coedited a book, Molecular Pathology: Ap- efforts. It should be evident that molecular pathology and proaches to Diagnosing Human Disease in the Clinical diagnostics impact almost every conceivable subspecialty Laboratory, that coined the phrase "molecular pathology" in laboratory medicine and, particularly in the case of to refer to applications of molecular biology in the tradi- pharmacogenomics, have led to the development of new tional areas of laboratory medicine. That compilation of areas of investigation. clinical molecular techniques included 11 chapters and an What is less evident is the burden placed upon the epilogue on "New Directions for the Clinical Laboratory. " laboratorians directing these efforts. Issues regarding Chapter headings included: automation, neoplasia, heri- training, certification, continuing education, and re- table diseases, and infectious diseases. bursement (just to name a few) have demanded enormous Three years later, in 1997, Bill Coleman and Greg Tson- time and effort from professional organizations and g- galis edited Molecular Diagnostics: For the Clinical ernmental agencies. In addition, because conventional Laboratorian, which contained 18 chapters and introduced approaches cannot always be applied to molecular di- the new areas of RT-PCR and In Situ PCR, and included nostics, unique solutions for quality assurance and quality a section on gene therapy. Now, ten years after the intro- control must be developed. These challenges have eng- duction of molecular pathology, we are looking at the dered committees, subcommittees, taskforces, and second edition of Bill Coleman and Greg Tsongalis' text.

Inhaltsverzeichnis

Part I. Introduction


An Historical Perspective on the Clinical Diagnostic Laboratory

Robert E. Moore


Part II. Basic Molecular Biology


An Overview of Nucleic Acid Chemistry, Structure, and Function: The Foundations of Molecular Biology

William B. Coleman


Extraction of Nucleic Acids

Paul N. Bogner and Anthony A. Killeen


Nucleic Acid Blotting Techniques: Theory and Practice

Terry Amiss and Sharon Collins Presnell


The Polymerase Chain Reaction

William B. Coleman and Gregory J. Tsongalis


Bioinformatics: Computer-Based Approaches to Genetic Analysis

Sharon L. Ricketts


Part III. Molecular Diagnostic Technologies


PCR-Based Methods for Mutation Detection

Ian M. Frayling, Emma Monk, and Rachel Butler


Alternative Methods for Amplified Nucleic Acid Testing

Deborah A. Payne and Laurie E. Sower


Electrophoretic Methods for Mutation Detection and DNA Sequencing

W. Edward Highsmith, Jr.


Single-Nucleotide Polymorphisms: Testing DNA Variation for Disease Association

Ulrich Broeckel and Martin J. Hessner


Microarray Approaches to Gene Expression Analysis

David Neil Hayes and Matthew Meyerson


Methods for Analysis of DNA Methylation

Alexander Dobrovic


Part IV. Other Clinical Diagnostic Technologies


Flow Cytometry

Joseph A. DiGiuseppe


Medical Cytogenetics

Martha B. Keagle


Fluorescence In Situ Hybridization: A Major Milestone in Luminous Cytogenetics

Suneel D. Mundle and Robert J. Koska


Immunohistochemistry

John Hunt, Larissa Davydova, Richard W. Cartun, and Maria Baiulescu


Laser Capture Microdissection

C. Robert Bagnell, Jr.


Part V. Quality Assurance in the Molecular Diagnostics Laboratory


Framework for Quality Assurance in Molecular Diagnostics

Marlene Sabbath-Solitare, Selwyn J. Baptist, and Teresita Cuyegkeng Redondo


Verification of Molecular Assays

Brent L. Seaton


Standards and Standardization of Molecular Diagnostics

John P. Jakupciak and Catherine D. O'Connell


Laboratory-Developed Tests in Molecular Diagnostics

Andrea Ferreira-Gonzalez and Carleton T. Garrett


Part VI. Applications of Molecular Diagnostics for Genetic Diseases


An Overview of Molecular Genetics

Elaine Weidenhammer and Gregory J. Tsongalis


Genetic Basis of Neurologic and Neuromuscular Diseases

Narasimhan Nagan, Christopher J. Klein, D. Brian Dawson, Myra J. Wick, and Stephen N. Thibodeau


Molecular Mechanisms of Endocrine Disorders

Amy Potter and John A. Phillips III


Molecular Pathogenesis of Cardiovascular Disease

Alan H. B. Wu


Molecular Diagnostics in Coagulation

Enrique Ballesteros


Cystic Fibrosis

Eugene H. Lewis III, Myra J. Lewis, Jean A. Amos, and Gregory J. Tsongalis


Prenatal Genotyping for Identification of Fetuses at Risk for Immune Cytopenic Disorders

Martin J. Hessner and Brian R. Curtis


Personalized Medicine, Karen McCullough


Part VII. Applications of Molecular Diagnostics for Human Cancers


Molecular Pathogenesis of Human Cancer

William B. Coleman and Gregory J. Tsongalis


Application of Molecular Diagnostics to Hereditary Nonpolyposis Colorectal Cancer

Ian M. Frayling, Lisa Happerfield, Christopher Mattocks, Kim Oakhill, and Mark J. Arends


Molecular Genetic Applications to the Diagnosis of Lymphoma

William N. Rezuke, Jr. and Gregory J. Tsongalis


Molecular Genetic Abnormalities in Acute and Chronic Leukemias

Pei Lin and L. Jeffrey Medeiros


Part VIII. Applications of Molecular Diagnostics for Infectious Diseases


Molecular Testing for Chlamydia trachomatis and Neisseria gonorrhoeae

Alexandra Valsamakis


Human Papillomavirus

Theresa M. Voytek and Gregory J. Tsongalis

Pressestimmen

"This is a great book to have handy for ready reference in this rapidly evolving field. While the reader may not use this reference daily, there is no question that it will be needed for those occasions when such testing is ordered and a clinical consultation between the clinical laboratory and the healthcare provider is necessary." - Doody's Health Sciences Book Review Journal
"...the textbook of choice for anyone working in molecular diagnostics who wants to remain current with this rapidly changing field. -Clinical Laboratory International
From Reviews of the First Edition...
"...a very good introduction to the basic elements of molecular pathology...a clear, enjoyable read...an excellent discussion of methods." -Clinical Chemistry
"...highly recommended...for those interested in clinical molecular diagnosis...will satisfy those who are more expert in certain areas of molecular diagnosis, but who have been unable to keep up with the wide range of recent advances in molecular diagnosis." -American Journal of Clinical Pathology
"...gives a good theoretical background for those with little experience in this field. It is readable, comprehensive, and...up-to-date." -Journal of Clinical Pathology
"...well written, comprehensive...should bring even the reader with limited background knowledge up to speed on what is a rapidly progressing field." -Trends in Molecular Medicine
"...a timely and highly relevant book that will serve as a valuable resource to those practicing molecular diagnostics from the bench, as well as to basic and clinical scientists..." -Endocrine News
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