Carnitine Deficiency and Insufficiency in Medicine

This book provides an in-depth examination of carnitine, a crucial nutrient for mitochondrial function and energy metabolism. It explores the discovery, biochemical properties, and physiological roles of carnitine, offering a comprehensive understanding of its significance in human health.

The chapters cover a wide range of topics, including the carnitine cycle, its transport mechanisms, and the biochemical pathways it influences. Readers will gain insights into the nutrient's newly discovered roles, such as its anti-inflammatory, antioxidant, and anti-apoptotic effects. The book also addresses the clinical implications of carnitine deficiency, exploring its impact on inherited metabolic diseases, kidney and liver disorders, and cardiovascular health. With detailed discussions on the safety and pharmacokinetics of carnitine, this volume provides a balanced perspective on its therapeutic potential.

This book is an invaluable resource for medical professionals, researchers, and students in the fields of biochemistry, pharmacology, and clinical medicine. It offers a thorough exploration of carnitine's roles and applications, making it a must-read for those seeking to understand its impact on health and disease. By bridging the gap between basic science and clinical practice, this book equips readers with the knowledge needed to address the challenges of carnitine deficiency and harness its therapeutic benefits.

1. The Discovery of Carnitine. - 2. Establishing the Carnitine Cycle. - 3. What is Carnitine? . - 4. Homeostasis of Carnitine. - 5. What is Carnitine Deficiency and Carnitine Insufficiency? . - 6. Appetite Enhancement and Digestive Enzyme Secretion Stimulating Effects of Carnitine. - 7. Anti-inflammatory, Antioxidant, and Anti-apoptotic Effects of Carnitine. - 8. Quantification and Pharmacokinetics of Carnitine. - 9. Safety of Carnitine. - 10. Carnitine Deficiency in Inherited Metabolic Diseases. - 11. Tube Feeding, Total Parenteral Nutrition (TPN), Specialty Milk Formula and Carnitine Deficiency. - 12. Carnitine Deficiency Due to Sodium Valproate. - 13. Carnitine Deficiency caused by Antibiotics Containing Pivoxil Group. - 14. Carnitine Deficiency in Patients with Liver Diseases. - 15. Carnitine Deficiency in Patients with Liver Diseases. - 16. Cardiovascular Diseases and Carnitine Deficiency. - 17. Other Diseases and Carnitine. - 18. Guidelines for Diagnosis and Treatment of Carnitine Deficiency. - 19. Clinical Pharmacological Issues with Carnitine.