Cardiac Remodeling

Part I: Molecular mechanisms of remodeling in pressure and volume overload hypertrophy and ehart failure. - ß-adrenergic receptor signaling pathway in heart failure. - Remodeling of potassium channels in cardiac hypertrophy. - Role of gender in Ca²⁺ cycling and cardiac remodeling due to heart failure. - The failing heart: is it an inefficient engine or an engine out of fuel? . - Regulation of cardiac hypertrophic remodeling by the USP15/SLIM1 pathway. - Role of galectin-3 pathways in the pathogenesis of cardiac remodeling and heart failure. - A mitochondriocentric pathway to cardiomyocyte necrosis: an upstream molecular mechanism in myocardial fibrosis. - The ACE2/Ang (1-7) pathway in cardiac remodeling due to pressure-overload. - Local actions of natriuretic peptides and nitric oxide in cardiac remodelling: Implications for therapy. - Modulating G protein-coupled receptors to effect reverse cardiac remodeling. - Role of inflammation and matrix proteinases in cardiac remodeling following stress and injury. - Role of chymase in matrix and myocardial remodeling due to mitral regurgitation. Implications for therapy. - Cardiac remodeling due to aortic regurgitation and mitral regurgitation. - Reducing oxidative stress and manipulating molecular signaling events using resveratrol as a therapy for pathological cardiac hypertrophy. - Angiogenesis, arteriogenesis, and mitochondrial dysfunction. - Part II: Molecular mechanisms of remodeling after myocardial injury and infarction. - Subcellular remodeling and cardiac dysfunction due to ischemia-reperfusion injury. - Role of microRNAs in cardiac hypertrophy and post-infarction remodeling. - Negative regulators of inflammation as endogenous protective mechanisms in post-infarction remodeling. - TLR-dependent pathways and Akt/mTOR/P70^S6K pathways in cardiac remodeling after myocardialinfarction. - The STAT3 pathway and downstream mechanisms in cardiac remodeling: Friend or foe. - The role of growth differentiation factor 5 in cardiac repair post myocardial infarction. - Extracellular matrix biomarkers of adverse remodeling after myocardial infarction. - Oxidative stress in cardiac repair and remodeling: Molecular pathways and therapeutic strategies. - Role of SPARC in cardiac extracellular matrix remodeling after myocardial infarction. - Tissue inhibitor of matrix metalloproteinases in the pathogenesis of heart failure syndromes. - Intracellular matrix remodeling and cardiac function in ischemia-reperfusion injury. - Aging and markers of adverse remodeling after myocardial infarction. - Optimizing stem cell therapy for cardiac repair following a myocardial infarction. - Regulation of fibrosis after myocardial infarction. Implications for ventricular remodeling. - The ACE2/Ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling.