Re-EngineeringoftheDamagedBrainandSpinalCord isdedicatedtoTetsuoKanno, M. D. ProfessorofNeurosurgery Bypresenting theoriginal papers thatmakeupthis thefeaturesofthelocalmedicallandscapeinthe- third supplement we wish to make a further contri- gionswheretheyareenacted. Whatismore, progr- bution to the issue of functional rehabilitation, this sivenew? ndingsmustbealsosubjectedtoafrequent soimportantandfascinatingmodernareaofresearch revision. Ontopofthis, itshouldnotbeforgottenthat inthe? eldofneurosciences. Thecongresspaperswe even when committal therapy guidelines are c- haveselectedconstituteagoodre? ectionofthetrans- sistentlyapplied, thereareconsiderablevariationsin disciplinary objectives. The literature references are therangeofpotentialcomplicationsandintheo- designedasaguidetoleadtheinterestedreadertoa comeofprospectivecontrolledmulti-centreandmul- deeperandmoredetailedunderstandingoftheindi- nationalstudiesontheissueofqualitymanagement. vidualissues. Functionalrehabilitationhasbeenanoriginaltask The demand for evidence-based medicine is well ofneurosurgeryfromtheveryoutset. The1990shave justi? ed; however, it rapidly comes up against the enteredtheannalsofbrainresearchasthe Decadeof limitsoffeasibility, especiallywherecontrolledthe- theBrain . Sincethentherehasbeenaneverstronger peuticstudiesareconcerned. TheCochrancollection growthofneuroscienti? cinterestworldwide, accom- of high-quality evidence-based healthcare databases paniedbysubstantial? nancialengagement. Thishas hasthusfarbeenofnohelptousindrawingupthe- primarily resulted in advances in basic neuro- peutic recommendations for the re-engineering of biologicalandneurophysiologicalresearchandalsoin brain and spinal-cord lesions. Today as ever, the thegrowthofneuroscienti? cknowledgeaboutbasic opinion of experts and empirically based medical mechanismsformotor control, paincontrol, aware- treatment and posttraumatic neurorehabilitation ness, cognition, learning and memory. The conse- continuetooccupyanindispensablepositionforthe quencemustbetoensurethattheadvancesmadeinthe everydayclinicalpracticeofneurosurgicalandneu- neuroscienti? cresearchareaareadequatelyexpanded traumatological therapies. Promising adjunct - intopracticalneurosurgicalcareandre-engineeringof proachesincludeneuropharmacology, forcascadesof brainandspinalcordlesionsandtoensureuponnew molecular interactions are known to be underlying approaches. Following this a fundamental path will activity-dependent plasticity and skills learning, as resultinanimprovedandmoree cientpreventionin many of these processes involve the major tra- thefuture, themeasuresthatstandrightatthefore- mitters. Furthermore, biologicalinterventionsby- front of all rehabilitation principles, meaning that ingendogenousneuronsandgliaaswellasexogenous conventionalconceptsmustbemodi? edtokeeppace stemcells, bone-marrowcells, macrophages, andother withthemoretask-speci? c, intensive, andprogressive types may promote the regeneration of nerve cells, demands. In this connection a series of guidelines, tissue, and neural circuitry. Class one studies have recommendations, and expert opinions and also beenmade, andnowclasstwostudieshavebeeni- algorithms have been elaborated by national and tiated, for example in connection with acute spinal international expert panels and multidisciplinary as- cord injury (SCI). The clinical application of fu- sociationsfortheacutemedicalcareofpatients.
Inhaltsverzeichnis
Evidence based neurorehabilitation. - Evidence based medicine in neurological rehabilitation a critical review. - Quality management in traumatic brain injury (TBI) Lessons from the prospective study in 6. 800 patients after acute TBI in respect of neurorehabilitation. - Posttraumatic epilepsy with special emphasis on prophylaxis and prevention. - Swallowing therapy a prospective study on patients with neurogenic dysphagia due to unilateral paresis of the vagal nerve, Avellis syndrome, Wallenberg s syndrome, posterior fossa tumours and cerebellar hemorrhage. - Impaired self-awareness after moderately severe to severe traumatic brain injury. - Assessment of health-related quality of life in persons after traumatic brain injury development of the Qolibri, a specific measure. - Re-engineering of brain lesions. - RNA editing: a molecular mechanism for the fine modulation of neuronal transmission. - Inhibition of I? B? phosphorylation prevents glutamate-induced NF-? B activation and neuronal cell death. - Reorganization of cerebral circuits in human brain lesion. - Transcranial magnetic stimulation in neurorehabilitation. - Is there impairment of a specific frontal lobe circuit in head injury? . - Treating the aging brain: cortical reorganization and behavior. - The localization of central pattern generators for swallowing in humans a clinical-anatomical study on patients with unilateral paresis of the vagal nerve, Avellis syndrome, Wallenberg s syndrome, posterior fossa tumours and cerebellar hemorrhage. - Functional regeneration of the axotomized auditory nerve with combined neurotrophic and anti-inhibitory strategies. - Electrically evoked hearing perception by functional neurostimulation of the central auditory system. - Physiological recordings from electrodesimplanted in the basal ganglia for deep brain stimulation in Parkinson s disease. The relevance of fast subthalamic rhythms. - DBS therapy for the vegetative state and minimally conscious state. - Deep brain stimulation for idiopathic or secondary movement disorders. - Extradural Motor Cortex Stimulation (EMCS) for Parkinson s disease. History and first results by the study group of the Italian neurosurgical society. - Endocrine dysfunction following traumatic brain injury: mechanisms, pathophysiology and clinical correlations. - Taylored implants for alloplastic cranioplasty clinical and surgical considerations. - Lessons from National and International TBI Societies and Funds like NBIRTT. - Re-engineering of spinal cord lesions. - Brachial plexus surgery (Honorary lecture). - Results in brachial plexus palsy after biceps neuro-muscular neurotization associated with neuro-neural neurotization and teno-muscular transfer. - Macrophages and dendritic cells treatment of spinal cord injury: from the bench to the clinic. - Electrophysiological effects of 4-aminopyridine on fictive locomotor activity of the rat spinal cord in vitro. - Alternative, complementary, energy-based medicine for spinal cord injury. - The effect of penile vibratory stimulation on male fertility potential, spasticity and neurogenic detrusor overactivity in spinal cord lesioned individuals. - Posttraumatic syringomyelia a serious complication in tetra- and paraplegic patients. - Functional neurorehabilitation in locked-in syndrome following C0 C1 decompression. - Treatment options and results in cervical myelopathy. - The treatment of the sacral pressure sores in patients with spinal lesions. - Neurological-neurosurgical-neurobehavioral rehabilitation. - Phenomenological aspects of consciousness itsdisturbance in acute and chronic stages. - Neuropsychological experiences in neurotraumatology. - Team care in ICU Psychotherapeutic aspects and taking care of family of patients with traumatic brain injury. - Early clinical predictive factors during coma recovery. - Predicting one year clinical outcome in traumatic brain injury (TBI) at the beginning of rehabilitation. - Severe brain injuries in children. - The locked-in syndrome: a challenge for therapy. - Addendum. - WFNS committee for neurorehabilitation. - Academia Multidisciplinaria Neurotraumatologica AMN. - NBIRTT, the National Brain Injury Research, Treatment and Training Foundation.
