This open access book, published under a CC BY 4. 0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Inhaltsverzeichnis
1. Quality in Non-GxP Research Environment. - 2. Guidelines & Initiatives for Good Research Practice. - 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices. - 4. General Principles of Preclinical Study Design. - 5. Resolving the tension between exploration and confirmation in preclinical biomedical research. - 6. Blinding and Randomization. - 7. Out of control? Managing baseline variability in experimental studies with control groups. - 8. Quality of Research Tools. - 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies. - 10. Building robustness intro translational research. - 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research. - 12. Minimum Information in In Vivo Research. - 13. A reckless guide to P-values: Local evidence, global errors. - 14. Electronic Lab Notebooks and Experimental Design Assistants. - 15. Data storage. - 16. Design of meta-analysis studies. - 17. Publishers responsibilities in promoting data quality and reproducibility. - 18. Quality governance in biomedical research. - 19. Good Research Practice Lessons from Animal Care & Use. - 20. Research collaborations and quality in research: foes or friends? . - 21. Costs of implementing quality in research practice.
