During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
Inhaltsverzeichnis
1. Clinical Aspects of Werner s Syndrome: Its Natural History and the Genetics of the Disease. - 2. Biochemical Roles of RecQ Helicases. - 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease. - 4. Proteins That Interact with the Werner Syndrome Gene Product. - 5. Sensitivity of Werner s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein. - 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging. - 7. Potential Function of the Werner s Syndrome Homologue in the African Clawed Frog and the Mouse. - 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism. - Replicative Senescence, Telomeres and Werner s Syndrome.
