Klick ins Buch Protein folding and misfolding als Buch (gebunden)

Protein folding and misfolding

Neurodegenerative Diseases. Auflage 2009. Gb. Sprache: Englisch.
Buch (gebunden)
Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson's and Alzheimer's dis … weiterlesen
Dieser Artikel ist auch verfügbar als:
Buch (gebunden)

192,49 *

inkl. MwSt.
Sofort lieferbar
Protein folding and misfolding als Buch (gebunden)


Titel: Protein folding and misfolding

ISBN: 1402094337
EAN: 9781402094330
Neurodegenerative Diseases.
Auflage 2009.
Sprache: Englisch.
Herausgegeben von Judit Ovádi, Ferenc Orosz
Springer-Verlag GmbH

15. Januar 2009 - gebunden - XIV


It was twenty ?ve years ago this year that for the ?rst time a protein under- ing a form of human cerebral amyloidosis, the Icelandic-type hereditary cerebral haemorrhage was identi?ed. This, together with the recognition that an amino acid substitution can transform the wild type cystatin C into a disease-associated amyloid-forming protein in this condition, was only a prelude to a series of imp- tant discoveries that followed. As a result, pathologically altered proteins have been brought into the centre stage of research into the pathomechanism of a n- ber of neurodegenerative diseases, which include epidemiologically such important conditions as Alzheimer s disease or Parkinson s disease and, among others, also the transmissible spongiform encephalopathies, Huntington s chorea, spinocereb- lar ataxias, frontotemporal lobar degenerations and amyotrophic lateral sclerosis. Despite the diversity in the amino acid sequence of the different proteins involved in these neurological diseases, one of the common themes underlying the patho- chanisms of all these conditions is protein misfolding, aggregation hence the term protein folding disorders , which can trigger cascades of events ultimately resulting in synapse loss and neuron death with devastating clinical consequences in many of the most precious spheres of human existence including personality, cognition, memory, skilled movements and affection. It is always a challenging task to unite the different topics of the individual ch- ters into a common theme in a multi-author volume, but the current book edited by Judit Ovadi and Ferenc Orosz ?ts this task admirably.


1. Structural Disorder and Its Connection with Misfolding Diseases; Veronika Csizmok and Peter Tompa. 1.1 The Concept of Protein Disorder. 1.2 Biophysical and Bioinformatics Characterization of Disorder. 1.2.1 Biophysical Techniques 1.2.2 Bioinformatics Techniques. 1.3 Disorder in Vivo, the Effect of Crowding? 1.4 Disorder and Aggregation. 1.5 Disorder in Neurodegenerative Diseases. 1.6 Physiological Prions. 1.7 Structural Transition to Amyloid: Partially Folded Intermediates. 1.8 The Structure of Amyloid: Cross-Beta Models and Flexibility. 1.9 Conclusions. References. 2 Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases Vladimir N. Uversky. 2.1 Neurodegenerative Diseases as Proteinopathies. 2.2 Introducing Intrinsically Disordered Proteins. 2.2.1 Concept. 2.2.2 Experimental Techniques for IDP Detection. 2.2.3 Sequence Peculiarities of IDPs and Predictors of Intrinsic Disorder. 2.2.4 Abundance of IDPs and their Functions. 2.3Abundance of IDPs in Neurodegenerative Diseases. Evidence from the Bioinformatics Analyses. 2.4 Intrinsic Disorder in Proteins Associated with -Protein and Alzheimer's Disease. 2.4.2 Neurodegenerative Diseases. 2.4.1 Amyloid Tau Protein in Alzheimer's Disease and Other Tauopathies. 2.4.3 Prion Protein and Prion Diseases. 2.4.4 Synucleins - and Synuclein and Synucleinopathies. 2.4.5 Parkinson's Disease and Dementia with Lewy Bodies. 2.4.6 Polyglutamine Repeat Diseases and Huntingtin, Ataxin-1, Ataxin-3, androgen Receptor and Atrophin-1. 2.4.7 Abri Peptide and Familial British Dementia. 2.4.8 Adan in Familial Danish Dementia. 2.4.9 Glial Fibrillary Acidic Protein and Alexander and Alpers Disease. 2.4.11DNA Disease. 2.4.10 Mitochondrial DNA Polymerase Excision Repair Protein ERCC-6 and Cockayne Syndrome. 2.4.12 Survival of Motor Neurons Protein and Spinal Muscular Atrophy. 2.5 Concluding Remarks: Another Illustration of the D2 Concept. References. 3 Dynamic Role of Ubiquitination in the Management of Misfolded Proteins Associated with Neurodegenerative Diseases. Esther S.P. Wong, Jeanne M.M. Tan and Kah-Leong Lim. 3.1 Protein Misfolding and the Ubiquitin-Proteasome System. 3.2 Protein Misfolding, UPS Disruption and Neurodegeneration. 3.3 Diversity of Ubiquitin Modifications. 3.4 Non-Proteolytic Ubiquitination and Protein Inclusions Biogenesis. 3.5 Aggresomes Formation and Clearance. 3.6 K63-Linked Polyubiquitination - A Novel Cargo Recognition Signal For Autophagic Degradation. 3.7 A Model of Inclusion Biogenesis and Clearance. 3.8 E2/E3 Pairs - Triage officers?. 3.9 Conclusions. References. 4. Protein Misfolding and Axonal Protection in Neurodegenerative Diseases. Haruhisa Inoue, Takayuki Kondo and Ryosuke Takahashi. 4.1 Neuronal Dysfunction in Neurodegeneration Are Reversible Process. 4.2 Neuronal Dysfunction Is Not Treatable by Anti-Cell Death Therapy. 4.3 Morphological Aspects of Neuronal Dysfunction Caused by Protein Aggregation/Misfolding in Human Neurodegenerative Disorder. 4.4 Protein Misfolding and Axonal Degeneration in Experimental Animal Models. 4.5 Therapeutic approaches to treat neuronal dysfunction by axonal protection. 4.5.1 Axonal regeneration. 4.5.2 Anti-Wallerian Degeneration. 4.5.3 Autophagy Enhancement. 4.5.4 Stabilization of Microtubules. 4.6 Concluding remarks. References. 5. Endoplasmic Reticulum Stress in Neurodegeneration Jeroen J.M. Hoozemans and Wiep Scheper. 5.1Introduction. 5.2 Protein Quality Control in the Endoplasmic Reticulum. 5.2.2 Triage: ERAD. 5.2.3 Degradation: Ubiquitin Proteasome System and Autophagy. 5.2.4 Stress Response: The Unfolded Protein Response. 5.2.5 ER-Stress-Induced Cell Death. 5.3. ER Stress in Neurodegenerative Disorders. 5.3.1 Alzheimer's Disease. 5.3.2 Parkinson's Disease 5.3.3 Prion Disease. 5.3.4 Tauopathies. 5.3.5 Polyglutamine Diseases. 5.3.6 Amyotrophic Lateral Sclerosis. 5.3.7 White Matter Disorders. 5.4 Conclusions .References. 6. Involvement of Alpha-2 Domain in Prion Protein Conformationally-Induced Diseases Luisa Rong

Mehr aus dieser Reihe

Molecular Dynamics Analyses of Prion Protein Structures
Buch (gebunden)
von Jiapu Zhang
Molecular Structures and Structural Dynamics of Prion Proteins and Prions
Buch (gebunden)
von Jiapu Zhang
Identification of Ligand Binding Site and Protein-Protein Interaction Area
Buch (gebunden)
NMR in Biological Systems
Buch (gebunden)
von K. V. R. Chary, …
Fundamentals of Protein NMR Spectroscopy
Buch (gebunden)
von Gordon S. Rule, …
089 - 70 80 99 47

Mo. - Fr. 8.00 - 20.00 Uhr
Sa. 10.00 - 20.00 Uhr
089 - 30 75 75 75

Mo. - Sa. 9.00 - 20.00 Uhr
Sicher & bequem bezahlen:
Bleiben Sie in Kontakt:
Zustellung durch:
1 Mängelexemplare sind Bücher mit leichten Beschädigungen, die das Lesen aber nicht einschränken. Mängelexemplare sind durch einen Stempel als solche gekennzeichnet. Die frühere Buchpreisbindung ist aufgehoben. Angaben zu Preissenkungen beziehen sich auf den gebundenen Preis eines mangelfreien Exemplars.

2 Diese Artikel unterliegen nicht der Preisbindung, die Preisbindung dieser Artikel wurde aufgehoben oder der Preis wurde vom Verlag gesenkt. Die jeweils zutreffende Alternative wird Ihnen auf der Artikelseite dargestellt. Angaben zu Preissenkungen beziehen sich auf den vorherigen Preis.

4 Der gebundene Preis dieses Artikels wird nach Ablauf des auf der Artikelseite dargestellten Datums vom Verlag angehoben.

5 Der Preisvergleich bezieht sich auf die unverbindliche Preisempfehlung (UVP) des Herstellers.

6 Der gebundene Preis dieses Artikels wurde vom Verlag gesenkt. Angaben zu Preissenkungen beziehen sich auf den vorherigen Preis.

7 Die Preisbindung dieses Artikels wurde aufgehoben. Angaben zu Preissenkungen beziehen sich auf den vorherigen Preis.

* Alle Preise verstehen sich inkl. der gesetzlichen MwSt. Informationen über den Versand und anfallende Versandkosten finden Sie hier.