Regenerative medicine is a relatively new field of medical science with vast potential in different clinical applications. Stem Cell-Based Tissue Repair presents a wide range of approaches on stem cell-based regenerative medicine. The first part of the book introduces the reader to the history and different aspects of basic and applied stem cell research. It presents different sources of progenitor or stem cells whilst comparing their abilities. The difficulties in the practical derivation and application of stem cells from different sources are discussed. A more comprehensive overview of stem cell-based and matrix association in the attempt to regenerate organs with stem cell engineering is presented in parts two and three. The advantages and problems associated with the interactions of stem cells with different scaffold matrices, the differentiation potential of stem cells and the major difficulties associated with the application of stem cells for clinical practice are discussed. Issues relating to stem cell-based tissue regeneration and the possible immunomodulation and homing of stem cells and issues relating to the ability to establish good manufacturing practice are also addressed. The contributors to this book include experts from a wide range of different areas of regenerative medicine. They present their different points-of-view and possible approaches for tissue regeneration, as well as relevant considerations on how to incorporate the wide range of stem cell sources in different regenerative treatment regimens. It will be a valuable reference resource for students and researchers involved in cell biology, tissue engineering and regenerative medicine.
Inhaltsverzeichnis
PART I: Stem cells sources for practical regenerative medicine; Clinical applications of stem cells; Embryonic and adult HSC; Adult non-hematopoietic stem cells: characterization, isolation; Screening Approaches for the Characterization of Stem Cells for regenerative medicine; Part II: TISSUE REGENERATION and STEM CELL ENGINEERING; MSC as vector for cancer therapies; Promises limitations in adult cell based tissue regeneration; Re-programming stem cells and induced adult stem cells; Culturing non-hematopoietic stem cells and requirements of GMP in stem cell based therapies; Stem cells as vectors of genes; PART III: ORGAN TRAGETTED TISSUE REPAIR WITH STEM CELLS; Regeneration of bone; Regeneration of cartilage; Stem cells based replacement tissue for muscle and heart repair; Regeneration of the vasculature; Regeneration of the pancreas/islets and liver; Treating neurodegenerative tissue with embryonic stem cells; Regeneration of the genitourinary system; Strategies to adjust immunomodulation by adult stem cells; Engineering of stem cell homing and labelling of stem cells
