Titel: Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Softcover reprint of the original 1st ed. 2014.
Herausgegeben von Constanze Bonifer, Peter N. Cockerill
Springer Berlin Heidelberg
23. August 2016 - kartoniert - 432 Seiten
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.
Preface.- Introduction.- The epigenetic regulatory machinery by Constanze Bonifer and Peter N. Cockerill.- Non-mammalian hematopoiesis.- What can we learn from flies: Epigenetic mechanisms regulating blood cell development in Drosophila by Paul Badenhorst.- Epigenetic and transcriptional mechanisms regulating blood cell development in zebrafish by Xiaoying Bai.- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function.- Epigenetic and transcriptional mechanisms regulating the development of the hematopoietic system in mammals by Maud Fleury, Flor M. Perez-Campo, Guilherme Costa, Georges Lacaud and Valerie Kouskoff.- Polycomb complexes: chromatin regulators required for cell diversity and tissue homeostasis by Miguel Vidal.- The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis by Vincent van den Boom, Hein Schepers, Annet Z. Brouwers-Vos, and Jan Jacob Schuringa.- Role of the Trithorax (MLL) - HOX axis in HSC development, function and leukaemia by Robert Slany.- Role of DNA methyltransferases and DNA methylation in cell fate decisions during blood cell development and leukemia by Grant A. Challen and Jenny J. Trowbridge.- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development.- Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis by Peter Laslo and Tomas Stopka.- The molecular basis of normal Erythroid/Megakaryocyte development and mechanisms of epigenetic/transcriptional deregulation leading to erythroleukemia and thalassemia by Douglas Vernimmen.- The molecular basis of T cell development and how epigenetic/transcriptional deregulation leads to T-ALL by Will Bailis and Warren Pear.- Epigenetic control of T cell receptor locus rearrangements in normal and aberrant conditions by Beatriz del Blanco, Úrsula Angulo, and Cristina Hernández-Munain.- The molecular basis of B cell development and the role of deregulated transcription and epigenetics in leukaemia and lymphoma by Christopher M. Kirkham, James N. Scott, Joan Boyes and Sarah Bevington.- Epigenetic control of immune cell function.- Epigenetic control of immune T cell memory by Atsushi Onodera, Damon J. Tumes, and Toshinori Nakayama.- The macrophage epigenome and the control of inflammatory gene expression by Sara Polletti, Alessia Curina, Gioacchino Natoli and Serena Ghisletti.- Subject index.