A panel of expert clinical and basic investigators summarize the state-of-the-art in the use of transgenic technology in a broad range of endocrinological applications. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology and its pathologies through mouse models, and provides a host of creative approaches to understand better the complex processes that are characteristic of hormonal systems.
Inhaltsverzeichnis
1 Germline Genetic Engineering Techniques in Endocrinology. - 2 The Transgenic Mouse in Studies of Mammalian Sexual Differentiation. - 3 The In Vivo Function of Müllerian-Inhibiting Substance During Mammalian Sexual Development. - 4 Control of Ovarian Function. - 5 Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression. - 6 Functional Analysis of the Bcl2 Gene Family in Transgenic Mice. - 7 The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis. - 8 Gene Knockout Approaches to Steroidogenesis. - 9 The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo. - 10 Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development. - 11 Prolactin and the Prolactin Receptor. - 12 Transgenic Models for Oxytocin and Vasopressin. - 13 Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function. - 14 Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation. - 15 Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System. - 16 Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity. - 17 Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors. - 18 Use of Transgenic Animals in Skeleton Biology. - 19 Transgenic Mouse Models of Prostate Cancer. - 20 Neural- and Endocrine-Cell-Specific Immortalization Using Transgenic Approaches.
