Studies on Respiratory Disorders

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

Introduction to oxidative stress and anti-oxidant therapy. - Role of reactive oxygen and nitrogen species in respiratory diseases: general considerations. - Role of exhaled biomarkers volatiles and exhaled breath condensate. - Pulmonary infections and oxidative injury. - Role of reactive oxygen species in causing acute lung injury. - Free radicals in pulmonary tuberculosis. - Oxidative injury caused by smoking and air-pollution. - Oxidative stress in chronic obstructive pulmonary disease. - Oxidative stress in asthma and allergic disease. - Oxygen free radicals in pulmonary hypertension. - Pulmonary fibrosis and oxidative stress. - Oxidant injury in sarcoidosis and other granulomatous disorders. - Oxidative stress in lung cancer. - Pulmonary toxicity from drugs, heavy metals and other poisonings oxidant injury and role of anti-oxidants. - Oxidative stress and respiratory muscle dysfunction. - The critical role of Nrf2. - Development of novel antioxidants. - Asbestosis.