This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.
Inhaltsverzeichnis
Preface. - Mitochondrion: A novel center for cancer cell signalling. - Exploiting BH3 mimetics for cancer therapy. - Regulation of mitochondrial function by MicroRNA. - Mitochondrial complex II as a target for anti-cancer drugs. - Exploiting celecoxib in cancer therapy. - Activation of mitochondria-driven pathways by artemisinin and its derivatives. - Vitamin E analogues as prototypic mitochondria-targeting anti-cancer agents. - Targeting mitochondria of cancer cells: Mechanism and compounds. - Targets and strategies for the mitochondrial assault on cancer. - Emerging anti-cancer targets in mitochondria. - Relevance of mitochondrial functions and plasticity in tumor biology. - Crosstalk between p53 and mitochondrial metabolism. - Progression of cardiomyopathy in Friedreich s ataxia, a mitochondrial disease. - Index.
