This book is on the re-imagination of Indigenous Knowledge Systems (IKS) and practices in 21st century Africa. Framed from an anti-colonial perspective, the book critically interrogates epistemological erasures and injustices meted against African IKS and practices. It magnifies the different contexts where African IKS were and continue to be used effectively for collective and personal benefit. Beyond the legitimate frustration and disheartenment expressed by the contributors to this volume over the systematic colonial efforts to render inferior and delegitimate African systems of knowing and knowledge production, the book makes an important contribution to the quest to correct misconceptions and misrepresentations by Eurocentric thinkers and practitioners about African indigenous knowledges. The book makes an informed claim that the future and vibrancy of African indigenous knowledge and practices lie in how well scholars of knowledge studies and decoloniality in and on Africa are able to join hands in articulating, debating and fronting their vitality and relevance in varied real-life situations. More importantly, the book provides a re-invigorated overview and nuanced analyses of the important role and continued relevance of African IKS and practices in the understanding, interpreting and tackling of the social unfoldings of everyday life and dynamism. Without romanticising African IKS and practices, the book provides added insights and pointers on policy and trends. It is an important addition to critical debates on knowledge studies across fields.