Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Inhaltsverzeichnis
1;Cover ;1 2;Advances in Immunology;4 3;Copyright Page;5 4;TOC$Contents ;6 5;Contributors;10 6;CH$Chapter 1: T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other;14 6.1;1. Introduction;15 6.2;2. TCR Signaling Leading to Actin Cytoskeletal Remodeling;17 6.3;3. Cytoskeletal Control of IS Formation;31 6.4;4. Regulation of TCR-Mediated MTOC Polarization;41 6.5;5. F-Actin-Mediated Regulation of Integrins;44 6.6;6. Cytoskeletal Dynamics and Cell Migration;49 6.7;7. Conclusion;61 6.8;References;63 7;CH$Chapter 2: HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases;78 7.1;1. Introduction;81 7.2;2. Expression and Function of HLA-DQ Transgenes in Mice;82 7.3;3. HLA-DQ Transgenic Mice as Models for Human Allergies;87 7.4;4. Expression and Function of HLA-DR Transgenic Mice;90 7.5;5. HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins as Humans;97 7.6;6. Collagen-Induced Arthritis-Model for Human Rheumatoid Arthritis;99 7.7;7. Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis;105 7.8;8. Spontaneous Models for Human Type I Diabetes;120 7.9;9. Experimental Autoimmune Myasthenia Gravis;124 7.10;10. HLA and Gluten Sensitivity-Celiac Disease and Dermatitis Herpetiformis;126 7.11;11. Relapsing Polychondritis;129 7.12;12. Spontaneous Autoimmune Myocarditis;132 7.13;13. Experimental Autoimmune Thyroiditis;135 7.14;14. Experimental Autoimmune Uveitis;138 7.15;15. Bacterial Superantigens and Toxic Shock Syndrome;140 7.16;16. Concluding Remarks;145 7.17;References;146 8;CH$Chapter 3: Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule;162 8.1;1. Introduction;163 8.2;2. Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease;165 8.3;3. Role of Zn in the Immune Response;170 8.4;4. Role of Zn in Mast Cells;175 8.5;5. Zn Signaling;177 8.6;6. Conclusion and Future Prospects;180 8.7;Acknowledgements;182 8.8;References;182 9;CH$Chapter 4
: The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses;190 9.1;1. Introduction;192 9.2;2. Structure, Ligands, and Expression of the SLAM-Family Receptors;195 9.3;3. The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus;210 9.4;4. The SLAM-Associated Protein;214 9.5;5. The Protective Role of SAP in X-Linked Lympho-Proliferative Disease;220 9.6;6. The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B;226 9.7;7. The SLAM-Family Receptors in NK Cell Responses;227 9.8;8. The Role of the SLAM-Family in Lymphoid Cells;233 9.9;9. The Role of the SLAM-Family on Nonlymphoid Cells;241 9.10;10. Concluding Remarks;245 9.11;References;246 10;CH$Chapter 5: Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes;264 10.1;1. Introduction;266 10.2;2. A Minimal Signaling Kit Couples to Proximal Transducer Enzymes;267 10.3;3. Signal Initiation: BCR Clusters with an Open Conformation;268 10.4;4. SLP-65: A Gateway to Intracellular Signaling Pathways;272 10.5;5. Dynamic Regulation of the BCR-Triggered Ca2+ Response;274 10.6;6. Mechanism and Function of BCR-Induced Ras Activation;279 10.7;7. Concluding Remarks;285 10.8;References;285 11;IDX$Index;296 12;Contents of Recent Volumes;304 13;Color Plate Section;309
