Exposure-Response Modeling

This book explores a wide range of topics in exposure-response modeling, from traditional PKPD modeling to other areas in drug development and beyond. It incorporates numerous examples and software programs for implementing novel methods. The book emphasizes dose adjustment and treatment adaptation based on dynamic exposure-response models, illustrates how to apply causal inference to exposure-response modeling in pharmacometrics and epidemiology, and links exposure-response modeling to clinical decision making through model-based decision analysis.