Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.
- The Yin Yang of TCF/b-Catenin Signalling
- Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors
- p53 and Human Cancer: The First Ten Thousand Mutations
- Macrophage Stimulating Protein
- CD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic Value
- A Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability
Inhaltsverzeichnis
1;Cover;1 2;Contents;6 3;Contributors to Volume 77;8 4;Chapter 1. The Yin-Yang of TCF/b-Catenin Signaling;10 4.1;I. An Introduction to the Tcf Family;11 4.2;II. The HMG Box: DNA Binding and Bending;12 4.3;III. Context-Dependent Transactivation;13 4.4;IV. Functions of the Tcfs in Mammalian Development;15 4.5;V. Wingless/Wnt Signaling Pathways;16 4.6;VI. Tcf/b-Catenin Complexes: Bipartite Transcription Factors Involved in Wingless/Wnt Signaling;17 4.7;VII. Regulation of Tcf/b-Catenin Signaling;19 4.8;VIII. Regulation of Wingless/Wnt Target Genes by Tcfs: Activation versus Repression;24 4.9;IX. Tcf/b-Catenin Signaling and Cancer;26 4.10;References;30 5;Chapter 2. Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors;34 5.1;I. Introduction;35 5.2;II. Clinical Aspects of ErbB Receptors;38 5.3;III. How Does ErbB-2 Induce Cancer?;51 5.4;IV. Evolutionary and Developmental Aspects of the Multiplicity of ErbB Proteins;55 5.5;V. The ErbB Signaling Network;57 5.6;VI. ErbB-Directed Cancer Therapy;64 5.7;VII. Conclusions;70 5.8;References;71 6;Chapter 3. p53 and Human Cancer: The First Ten Thousand Mutations;90 6.1;I. Introduction;90 6.2;II. Biology of the p53 Protein;92 6.3;III. Mutations and Variations in the p53 Gene;109 6.4;IV. p53 Mutations in Sporadic Cancers: HostEnvironment Interactions;113 6.5;V. Clinical Relevance of p53 Mutations;128 6.6;References;132 7;Chapter 4. Macrophage Stimulating Protein;148 7.1;I. Introduction;148 7.2;II. Structural Aspects of Native and Recombinant pro-MSP;150 7.3;III. Binding of MSP to Its Receptor;151 7.4;IV. A Model of MSP-Induced Receptor Dimerization;152 7.5;V. Regulation of MSP Activity: Pathways for pro-MSP Cleavage;153 7.6;VI. MSPRon Signaling;156 7.7;VII. Modes of MSP Receptor Regulation or Activation;161 7.8;VIII. Target Cells for Macrophage Stimulating Protein;166 7.9;IX. Perspective;170 7.10;References;171 8;Chapter 5. CD44 Glycoproteins in Colorectal Cancer: Expression, Function, and P
rognostic Value;178 8.1;I. Introduction;178 8.2;II. Structure and Function of CD44;179 8.3;III. CD44 in Tumor Progression and Metastasis;183 8.4;IV. Conclusions;191 8.5;References;191 9;Chapter 6. A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability;198 9.1;I. Introduction;199 9.2;II. A Simple Model of RER+ Tumor Carcinogenesis;202 9.3;III. Evidence to Support the Model;207 9.4;IV. Discussion;212 9.5;V. Conclusion;227 9.6;References;227 10;Index;232
