Reducing Mortality in the Perioperative Period

This second edition presents the first update on a consensus process during which all evidence from the literature with a survival benefit in the perioperative period was gathered, and in which 500 physicians from 61 countries worked to confirm the findings.

Perioperative morbidity and mortality currently represent a public health problem, as mortality alone is 1-4% in Western countries. Surprisingly, randomized evidence of survival benefit in the perioperative period is available for only 12 topics, while two drugs have been demonstrated to increase mortality. This book offers a complete description of each topic with updated evidence from the literature. Each chapter deals with a specific drug or technique and is structured into the following: background knowledge, main evidence from the literature, and a practical how-to section. Lastly, the book describes in detail the consensus process used, which served to reinforce the systematic review and which is currently being usedand improved in other settings with growing success.

Written by respected international experts,

Reducing Mortality in the Perioperative Period, 2
^nd
ed.

will be of interest to a wide variety of specialists, including anesthesiologists, intensivists, surgeons and cardiologists.

The Risks and Benefits of the Consensus Process.- The Process of Consensus Building.- Noninvasive Ventilation to Reduce Perioperative Mortality.- Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality.- Can Neuraxial Anesthesia Reduce Perioperative Mortality.- Role of Perioperative Hemodynamic Optimization in Reducing Perioperative Mortality.- Levosimendan to Reduce Perioperative Mortality.- Perioperative b-Blocker Therapy and Survival.- Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality.- Reducing Perioperative Mortality with Intra-Aortic Balloon Counterpulsation (IABP).- Selective Decontamination of the Digestive Tract.- Role of Insulin in Reducing Mortality in the Perioperative Period.- Aprotinin: Pharmacological Benefits and Safety Concerns.- Consensus Conference on Perioperative Mortality: An Update.- Liberal Transfusion Strategy in the Perioperative Period.- Remote ischaemic preconditioning.- Statins.- Tranexamic acid.- Proven mortalityreduction unconfirmed in most recent works. methodological problem.