Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.
This volume's companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.
Inhaltsverzeichnis
Basic Concepts of TGF-? Signaling in Normal Physiology and Cancer Pathobiology. - Component Hardware for Transforming Growth Factor-? Signal Transduction: TGF-? Ligands, TGF-? Receptors, and Smads. - TGF-? Signaling in Homeostasis and Cancer. - TGF-? Availability: Latent TGF-? and Latent TGF-? Binding Proteins. - Biological Functions of Latent TGF-? -Binding Proteins and Activation of TGF-? . - Regulators of Smad2/3 Transcription and Phosphorylation. - Interaction of Smad4 and Embryonic Liver Fodrin-? -spectrin in Hyperplasia, Neoplasia, and Tumor Suppression. - Regulation of Smad Activity by Phosphorylation. - Nuclear Targeting of TGF-? -Activated Smads in Normal and Tumor Biology. - Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival. - Transforming Growth Factor-? in Cancer Therapy: Smurfs in TGF-? Signaling and Regulation of Bone Homeostasis and Cancer. - Involvement of km23 Dynein Light Chains in TGF ? Signaling. - TGF-? Signaling in Fibroblastic Cells and Oncogenesis. - Mechanisms of TGF-? -Induced Apoptosis in Cancer Cells. - Mechanisms of Cell Cycle Regulation by TGF-? Disabled in Cancer. - Transforming Growth Factor-? in Cancer Therapy. - TGF-? and Smad Signaling in Transcriptome Reprogramming During EMT. - Functional Interactions Between MMPs and TGF-? in Normal and Tumor Tissue. - Cooperation Between TGF-? and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function. - Interaction of Oncogenic Ras and TGF? 1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model. - TGF-? Superfamily Members in Normal and Tumor Biology. - Proteomics Analysis of TGF? Superfamily Members. - Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain HumanCancers. - Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression. - Bone Morphogenic Proteins and Angiogenesis in Developing Tumors. - Histone Methyltransferase and Smad Interactions in BMP Signaling. - Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies. - Activins and Inhibins in Cancer Progression. - Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma. - Regulation of the Transforming Growth Factor-? Superfamily by Betaglycan. - Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney. - Role of Betaig-h3 Gene in Carcinogenesis. - Activins and the Liver. - Myostatin Signaling in Normal and Tumor Cells. - TGF-? in Inflammation and Fibrosis. - Triterpenoids, Vitamin D, and TGF-? /Smad Signaling in Inflammation and Cancer. - Thrombospondin-Dependent Activation of Latent TGF-? in Fibrosis and Disease. - TGF-? in Pulmonary Fibrosis. - The Role of TGF-? in Bleomycin Induced Pulmonary Fibrosis. - Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse. - TGF-? Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7. - Transforming Growth Factor-? Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema. - The Role of TGF-? in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-? as a Novel Therapeutic Strategy. - Negative Regulation of the TGF-? Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis. - TGF-? -Related Antifibrotic Strategies in the Eye. - Transforming Growth Factor-? in CutaneousTissue Repair. - Topical Application of TGF-? 1 Peptide Inhibitors for the Therapy of Skin Fibrosis. - Overexpressed Truncated TGF-? Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo.
