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Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa
subunit is an enzyme that in humans is encoded by the DDOST gene.This
gene encodes a component of the oligosaccharyltransferase complex which
catalyzes the transfer of high-mannose oligosaccharides to asparagine
residues on nascent polypeptides in the lumen of the rough endoplasmic
reticulum. The protein complex co-purifies with ribosomes. The product
of this gene is also implicated in the processing of advanced glycation
endproducts (AGEs), which form from non-enzymatic reactions between
sugars and proteins or lipids and are associated with aging and
hyperglycemia.
