How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems

How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated unit operations, along with their characterization and control. In addition, it discusses practical insights and strategies that the editor and chapter authors have learned. Chapters cover Process Analytical Technology (PAT) tools and the application of PAT data to enable distributed process control.

With numerous case studies throughout, this valuable guide is ideal for those engaged in, or learning about, continuous processing in pharmaceutical manufacturing.

1. Introduction - Current State of the Technology
2. Conceptual Design
3. Material Characterization
4. Loss-in-weight feeding
5. Continuous powder mixing
6. Roller compaction
7. Wet granulation
8. Continuous Drying
9. Continuous tableting and coating
10. Role of Process Analytical Technology in Continuous Manufacturing
11. Process modeling
12. Integrated process control
13. Real Time Release and Testing
14. Risk Analysis, Sensitivity, and Optimization
15. Regulatory Expectations
16. The future of continuous processing