Etomidate

The question how to induce general anaesthesia without problems has been asked repeatedly by anaesthetists and pharmacologists. P. A. JANSSEN developed etomidate and published this substance in 1971 as "a potent short-acting and relatively atoxic intravenous hypnotic agent in rats". In 1974 after several years of experimental and clinical trial the barbiturate-free hypnotic etomidate (soon marketed as Hypnomidate) was introduced to numerous auditors at the occasion of the IV. European Congress of Anaesthesiologists in Madrid. As the authors extended their essays, the actuality of the present book is given. The conclusion mentions the new solution of etomidate base in 35 % propylene glycol. It is expected that the disadvantageous effects - venous pain during injection and associated involuntary muscle movement- will largely be eliminated by using the new formula of etomidate after premedication of fentanyl. Mlinchen, August 1977 Alfred DOENICKE TABLE OF CONTENTS The Experimental Pharmacology of Etomidate, a New Potent, Short-Acting Intravenous Hypnotic (R. S. RENEMAN and P. A. JANSSEN) -. . . . -- 1 Protein Binding of Etomidate (G. A. MANNES and A. DOENICKE) ----. . . 6 The Effect of Intra-Arterial Injection of Etomidate and Thiopental on the Skeletal Muscle- and Arterial Wall-Structures (R. S. RENEMAN, F. VERHEYEN, R. KRUGER, W. VAN GERVEN and M. BORGES) . . -. . -- 9 Interaction between Etomidate and the Antihypertensive Agents Propanolol andoC-Methyl-Dopa (R. S. RENEMAN, W. VAN GERVEN and R. KRUGER) --. -. . . 15 Teratogenicity of Etomidate (A. DOENICKE and M. HAEHL) -. --. -.

The Experimental Pharmacology of Etomidate, a New Potent, Short-Acting Intravenous Hypnotic. - Protein Binding of Etomidate. - The Effect of Intra-Arterial Injection of Etomidate and Thiopental on the Skeletal Muscle- and Arterial Wall-Structures. - Interaction between Etomidate and the Antihypertensive Agents Propanolol and ? -Methyl-Dopa. - Teratogenicity of Etomidate. - Etomidate, A New Hypnotic Agent for Intravenous Application. - The EEG after Etomidate. - A Comparison of the Acute Effects of Intravenous Induction Agents (Thiopentone, Methohexitone, Propanidid, Althesin, Ketamine, Piritramide and Etomidate) on Haemodynamics and Myocardial Oxygen Consumption in Dogs. - Haemodynamic Effects of Etomidate a New Hypnotic in Patients with Myocardial Insufficiency. - Haemodynamics, Myocardial Function, Oxygen Requirement, and Oxygen Supply of the Human Heart after Administration of Etomidate. - Experimental Investigations on the Direct Effect of Etomidate on Myocardial Contractility. - The Influence of R 26 490 (Etomidate Sulfate) on Ventilation and Gas Exchange. - A Comparative Study of Blood Gases and Haemodynamics Using the New Hypnotic Etomidate, CT 1341, Methohexitone, Propanidid and Thiopentone. - The Use of Etomidate as an Induction Agent in Fentanyl Analgesia. - Etomidate Anaesthesia for Cardioversion. - Etomidate and Fentanyl for Emergency Anaesthesia in Acute Bleeding with Haemorrhagic Shock. - Clinical Experience with Etomidate in Diagnostical Interventions and Operations of Short Duration. - Etomidate as A New Drug in Intravenous Anaesthesia (Conclusion).