In his book, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans. These reactions are applicable to a range of substrates and proceed with excellent stereoselectivity.
In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
Inhaltsverzeichnis
Introduction. - Significance. - General Approaches to the Synthesis of Substituted Tetrahydropyrans. - Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions. - Introduction. - Preliminary Study. - Result and Discussion. - Synthesis of 4-Hydroxy-2, 6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2 Reaction.
