LC-MS in Drug Bioanalysis

Internal standards for quantitative LC-MS bioanalysis. - Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS. - Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry. - Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry. - Pitfalls of LC-MS/MS in the clinical laboratory. - Therapeutic drug monitoring to support clinical pharmacogenomics. - Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices. - The analysis of antipsychotic drugs in human biosamples by LC-MS. - Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective. - Applications of mass spectrometry in analyses of steroid hormones. - Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications. - Analysis of illicit drugs in human biological samples by LC-MSn. - Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs. - A planar integrated micro mass spectrometer.