Marburg Virus Disease

In the late summer of 1967, several patients suffering from a severe disease were admitted to the Department of Medicine of the Marburg University. It soon became obvious that the illness was a hitherto unknown infectious disease. The number of afflicted patients increased to 23. Several cases were observed in Frankfurt/Main at the same time and, some weeks later also in Belgrade, Yugo slavia. Common to all the patients was previous contact with the blood or tissues of Cercopithecus aethiops, the vervet monkey. Altogether 31 people became ill and 7 died. It was soon apparent that the infectious agent was neither bacterial nor rickettsial in origin but that a viral etiology was probable. Most of the known viral diseases were excluded and the infectious agent was shown to be a hitherto unknown virus with many peculiar characteristics: it infects guinea pigs but not adult mice and is larger than known viruses and of different shape. This agent was called the "Marburg virus" since most of the cases had occurred in Marburg and the greater part of the laboratory work leading to the detection of the virus was performed in Marburg.

Marburg Virus Disease. Clinical Syndrome. - Clinical Course and Prognosis of Marburg Virus ( Green-Monkey ) Disease. - Clinical Picture of Two Patients Infected by the Marburg Vervet Virus. - Two Cases of Cercopithecus-Monkeys-Associated Haemorrhagic Fever. - Haematological Findings in Marburg Virus Disease: Evidence for Involvement of the Immunological System. - Clinical Manifestations and Mechanism of the Haemorrhagic Diathesis in Marburg Virus Disease. - Pathologic Anatomy of the Marburg Virus Disease. - The Neuropathology of the Marburg Disease in Man. - Marburg Virus Hepatitis. - Morphology, Development, and Classification of the Marburg Virus. - Morphology and Morphogenesis of the Marburg Agent. - Absence of Serological Relationship Between the Marburg Virus and Some Arboviruses. - Biological Properties of the Marburg Virus. - Some Characteristics of the Marburg Virus. - Cultivation of the Marburg Virus (Rhabdovirus simiae) in Cell Cultures. - Passage of Marburg Virus in Guinea Pigs. - Histologic Findings in Livers and Spleens of Guinea Pigs after Infection by the Marburg Virus. - Neuropathological Findings in Experimentally Infected Guinea Pigs. - Marburg Disease . The Pathology of Experimentally Infected Hamsters. - Experimental Infection of Monkeys with the Marburg Virus. - The Morphological Picture in Livers, Spleens, and Lymph Nodes of Monkeys and Guinea Pigs after Infection with the Vervet Agent . - Laboratory Diagnosis and Pathogenesis. - Epidemiology of Marburg Virus Disease. - Epidemiological Studies in Uganda Relating to the Marburg Agent. - A Serological Survey of Primate Sera for Antibody to the Marburg Virus. - Studies on the Marburg Virus. - Examination of South African Primates for the Presence of Marburg Virus. - Epizootic, Clinical, andPathological Aspects of Simian Hemorrhagic Fever. - Simian Hemorrhagic Fever Virus. - Measures Taken by the Public Health Officials During the Marburg Virus Disease . - The Vervet Monkey Disease, Protection Against Occupational Hazards. - Legislative Measures Concerning the Importation of Monkeys. - W. H. O. Draft Recommendations for the Supply, Safe-Handling, and Use of Non-Human Primates for Biomedical Purposes. - Marburg Virus: Consequences for the Manufacture and Control of Virus Vaccines.