Microdialysis in Drug Development

Microdialysis is vital to drug development, with in vivo target-site concentrations a key determinant of a drug's effectiveness. This volume covers all current microdialysis technology, as well as general and disease-specific aspects of the techniques.

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

Introduction to the Microdialysis Technology. - Recovery and Calibration Techniques: Toward Quantitative Microdialysis. - Analytical Considerations for Microdialysis Sampling. - Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective. - Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations. - Microdialysis in Antibiotic Research. - Skin and Transdermal Drug Delivery: Advantages and Challenges. - Translational Approaches For Predicting CNS Drug Effects Using Microdialysis. - Extracellular Amyloid-ß Protein Dynamics in Alzheimer' s Disease. - Microdialysis in Pain Research. - Microdialysis in Ocular Drug Development. - Microdialysis in Metabolic Research. - High Molecular Weight Targets and Treatments Using Microdialysis. - Complementary Techniques Positron Emission Tomography. - Open Flow Microperfusion: An Alternative Method to Microdialysis? . - Microdialysis in Internal Organs and Tumors.