Orexin and Sleep
Molecular, Functional and Clinical Aspects
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This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.
Inhaltsverzeichnis
History of Orexin Research. - The Hypocretin Story. - Input and output systems of orexin neurons. - Physiological roles of orexin receptors on sleep/wakefulness regulation. - Orexin receptor functions in the ascending arousal system (Folder name - Leonard). - Elucidation of neuronal circuitry involved in the regulation of sleep/wakefulness using optogenetics (Folder name - Yamanaka). - Modulation of thalamocortical pathways by orexins. - Orexins, Alcohol and Sleep Homeostasis. - Orexin induced modulation of REM sleep and its loss associated patho-physiological changes are mediated through locus coeruleus. - Role of orexin on sleep: interactions with other neurotransmitter systems.
Produktdetails
Erscheinungsdatum
23. August 2016
Sprache
englisch
Auflage
Softcover reprint of the original 1st ed. 2015
Seitenanzahl
424
Herausgegeben von
Jaime M. Monti, S. R. Pandi-Perumal, Takeshi Sakurai
Verlag/Hersteller
Produktart
kartoniert
Abbildungen
XIV, 410 p.
Gewicht
639 g
Größe (L/B/H)
235/155/23 mm
Sonstiges
Paperback
ISBN
9783319352206
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Pressestimmen
This is an up-to-date look at these hypothalamic
neuropeptides and how we have come to understand their wide range of
neuroregulatory roles. This is highly technical book that reviews in detail
the research that has led to the discovery and understanding of the orexin
neuropeptides and their role in a wide range of neuromodulatory systems.
provide some insights into how manipulation of this system may result in
therapeutic interventions for a number of neurological and psychiatric
conditions. (Michael Easton, Doody s Book Reviews, February, 2016)
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