Regeneration of the lost periodontium is the ultimate goal of periodontal therapy. For this, growth factors are one of the requirements and platelet-rich fibrin (PRF) has been stated to be one of the richest sources of growth factors. PRF is an autologous non transfusional hemo-component with a high concentration of platelets. It incorporates platelets and leukocytes derived growth factors within the dense fibrin matrix and has been used as healing biomaterial. So, this thesis focuses on any additional effect of PRF along with osseous graft over osseous graft alone in the management of periodontal infrabony defects.
