Microfluidic Very Large Scale Integration (VLSI)

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.

Introduction. - Part 1. Preliminaries. - Design Methodology
for Flow-based Microfluidic Biochips. - Biochip Architecture Model. - Biochemical
Application Modeling. - Part 2. Compilation. - Compiling High-Level Languages. - Application
Mapping and Simulation. - Control Synthesis and Pin-Count Minimization. - Part 3.
Physical Design. - Allocation and Schematic Design. - Placement and Routing. - On-Chip
Control Synthesis. - Testing and Fault-Tolerant Design.