Advances in Metabolic Disorders discusses the uric acid and gout, the macroglobulins, the metabolism of testosterone in feminizing testes, tryptophan metabolism, and anabolic steroids. It defines the concept of nitrogen-retaining steroids and their use in disease. The book also explains the meaning of macroglobulinemia. The text examines the genetic factors in the development of gout. The technology involved in the control of purine synthesis is analyzed. The nucleotide degradation and uric acid synthesis are explained. The accumulation of uric acid in gout is discussed in detail. The formation of renal stone is explored. A chapter of the book focuses on a group of antibody molecules. This chapter also introduces cytology, hematology, and serology. A section of the volume is devoted to the source of macroglobulins, chromosomal aberrations, the analysis of urinary metabolites and the nature of macroglobulinemia. The book will provide useful information to doctors, students, and researchers in the field of medicine.
Inhaltsverzeichnis
1;Front Cover ;1 2;Advances in Metabolic disorders ;4 3;Copyright Page ;5 4;Table of Contents ;10 5;Contributors ;6 6;Preface ;8 7;Chapter 1. Gout ;12 7.1;I. Introduction;13 7.2;II. Serum Uric Acid Concentration ;13 7.3;III. Purine Biosynthesis;21 7.4;IV. Production of Uric Acid in Gout;31 7.5;V. Disposition of Uric Acid;42 7.6;VI. Renal Function in Gout;45 7.7;VII. Pathogenesis of Hyperuricemia in Primary Gout;53 7.8;VIII. Acute Gouty Arthritis;58 7.9;IX. Pathology of Chronic Gout;64 7.10;X. Primary and Secondary Gout;67 7.11;XI. Therapy;72 7.12;References;78 8;Chapter 2. Nitrogen-Retaining Steroids and Their Application in Disease ;90 8.1;I. Introduction;90 8.2;II. Pharmacological Evaluation of Nitrogen'Retaining Steroids ;92 8.3;III. Therapeutic Application of Nitrogen-Retaining Steroids;103 8.4;ACKNOWLEDGMENTS ;117 8.5;References;117 8.6;Addendum ;123 9;Chapter 3. Macroglobulinemia ;126 9.1;I. Introduction;126 9.2;II. Macroglobulinemia: Clinical Picture;130 9.3;III. The Macroglobulin;141 9.4;IV. Course, Prognosis, and Therapy;153 9.5;V. General Discussion;162 9.6;References;166 10;Chapter 4. Testing the Functional Capacity of the Tryptophan-Niacin Pathway in Man by Analysis of Urinary Metabolites ;170 10.1;I. Introduction;171 10.2;II. Metabolic Pathway from Tryptophan to Niacin;174 10.3;III. Quantitative Methods for Tryptophan Metabolites;177 10.4;IV. Ion-Exchange Resins, Columns, and Special Equipment ;204 10.5;V. Factors That Affect the Tryptophan-Niacin Pathway;210 10.6;VI. The Loading Dose of Tryptophan;219 10.7;VII. Comments on the Conduct of Clinical Studies;223 10.8;ACKNOWLEDGMENTS;229 10.9;References;230 11;Chapter 5. The Syndrome of Testicular Feminization;238 11.1;I. Introduction;238 11.2;II. Characteristics of the Syndrome;239 11.3;III. Endocrine Studies;251 11.4;IV. Comments and Pathogenesis;263 11.5;ACKNOWLEDGMENTS;264 11.6;References;265 12;Author Index ;268 13;Subject Index ;285
