Cushing s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing's syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing's syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.
Inhaltsverzeichnis
Physiology and Pathophysiology of the HPA axis. - Etiologies of Cushing s syndrome. - Pathogenesis of corticotropic tumors. - Pathogenesis of adrenocortical tumors. - Clinical features of Cushing s syndrome. - Laboratorial diagnosis of Cushing s Syndrome: Differential diagnosis with pseudo-Cushing s conditions as obesity, alcoholism and depression. - Laboratorial diagnosis of Cushing s syndrome: Differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing s syndrome. - Imaging for the differential diagnosis of Cushing s syndrome: MRI, CT and isotopic scanning. - Inferior petrosal sampling for the differential diagnosis of ACTH dependent Cushing s syndrome. - ACTH-dependent Cushing syndrome: Treatment of Cushing s disease. - Treatment of Cushings Syndrome: Surgical Treatment. - Adrenal-Directed Treatment Options for Cushing s Disease. - Radiation Therapy and Stereotactic Radiosurgery for Cushing s Disease. - Medical Management of Cushing s syndrome. - ACTH-dependent Cushing syndrome: Clinical and diagnostic aspects, and treatment approaches for ectopic Cushing s syndrome. - Revisiting the Nelson s syndrome: Corticotroph Tumor Progression after bilateral adrenalectomy in Cushing s disease. - ACTH-independent Cushing s syndrome: Adrenocortical tumors. - ACTH-independent Cushing s syndrome: Bilateral macronodular hyperplasia. - ACTH-independent Cushing s syndrome: primary pigmented nodular adrenal disease in the context of Carney s complex. - Glucocorticoid Resistance. - Post-operative replacement and assessment of HPA axis recovery in Cushing s syndrome. - Special aspects of Cushing s syndrome: Pregnancy. - Special aspects of Cushing s syndrome: Childhood. - Special aspects of Cushing s syndrome: Cyclic Cushing s syndrome.
