Aldol Reactions

Aldol Reactions provides a comprehensive up-to-date overview of aldol reactions including:

• Application of different metal enolates
• Catalytic aldol additions catalyzed by different Lewis acids and Lewis bases
• Enantioselective direct aldol additions
• Antibodies and enzyme catalyzed aldol additions
• The recent aggressive development of organocatalyzed aldol additions.

The power of each method is demonstrated by several applications in total synthesis of natural products. The pros and cons of these methodologies with regard to stereoselectivity, regioselectivity and application in total synthesis of natural products are discussed. Great importance is set to the diverse possibilities of the manual of aldol reaction to install required configurations in complicated natural product synthesis.

Aldol Reactions with Preformed Enolates. - Magnesium Enolates. - Boron Enolates. - Titanium Enolates. - Tin Enolates. - Catalytic Aldol Additions. - Lewis Acid-Catalysed Aldol Reactions. - Tin Lewis Acids. - Boron Lewis Acids. - Copper Lewis Acids. - Silver, Palladium and Platinum Lewis Acids. - Zirconium Lewis Acids. - Miscellaneous Lewis Acids. - Lewis Base-Catalysed Aldol Additions. - Direct Aldol Addition. - Gold- and Rhodium-Catalysed Aldol Additions. - Antibody-Catalysed Aldol Addition. - Enzyme-Catalysed Aldol Addition. - Organocatalysed Aldol Addition.