Titel: Exogenous Factors in Colonic Carcinogenesis
Herausgegeben von W. Scheppach, M. Scheurlen
31. Januar 2003 - gebunden - 344 Seiten
This book is the proceedings of Falk Symposium 128, held in Würzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic carcinogenesis and its underlying genetic and environmental factors. Colorectal cancer is one of the leading causes of cancer-related death in industrialized countries. It has been recognized to be the consequence of a dynamic process leading from hyperproliferative epithelium through different classes of adenomas to invasive carcinoma. This adenoma-carcinoma sequence has been characterized on a molecular basis. Modern molecular biology has also helped to clarify the clustering of colorectal cancer within families, a phenomenon that has been known to clinicians for a long time. Thus, the pathogenesis of the two distinct familial colon cancer syndromes FAP (familial adenomatous polyposis) and HNPCC (hereditary non-polyposis colorectal cancer) is increasingly being understood. Thereby, an identification of affected people has become possible before the disease has manifested. There is also convincing evidence that the pathogenesis of sporadic colonic cancer is modulated by environmental, mainly nutritional, factors. Carcinogens seem to be far less important than the components of the `normal' human diet. It is likely that the interplay between protective and noxious dietary compounds determines the progression of the adenoma-carcinoma sequence. Additionally, a broad spectrum of drugs has been shown to affect colonic tumorigenesis, which provides the rationale for chemoprevention strategies. These issues set the scene for discussions on how genetic and environmental factors may interact in the pathogenesis of colonic cancer, contributing fresh ideas to the prevention of this most prevalent malignancy in the industrialized world.
List of Principal Authors. Preface. Section I: Epidemiology and Risk Assessment. 1. Exposure and disease biomarkers for colorectal cancer risk; W.R. Bruce. 2. Exogenous factors in colonic carcinogenesis; B.L. Pool-Zobel. 3. Definition of cancer susceptibility; M.-C. Boutron-Ruault. 4. Epidemiology of colorectal cancer; M.J. Hill. Section II: Genetics and Molecular Mechanisms. 5. Molecular pathways in colorectal cancer development; J.R. Vass, et al. 6. Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms; F. Kullmann. 7. Hereditary non-polyposis colorectal cancer: pathogenesis and mechanisms; P. Rosen. 8. Possible molecular targets for exogenous factors; R.W. Owen, et al. Section III: Identification of Genetically Determined Risk Groups. 9. Hereditary versus environmental factors in colorectal cancer; L.H. Augenlicht. 10. Patient identification and surveillance in familial adenomatous polyposis (FAP); R. Caspari. 11. Patient identification and clinical management in hereditary non-polyposis colorectal cancer; O. Al-Taie. 12. Screening strategies for sporadic colorectal cancer (CRC) in the general population; C. Pox, et al. Section IV: Noxious Dietary Compounds. 13. Red meat: a dietary risk factor for colorectal cancer; H. Boeing, et al. 14. Types of dietary fat and colon cancer risk; B.S. Reddy, et al. 15. Alcohol and colorectal cancer; A. Chao, et al. 16.Potential link between sphingomyelin metabolism and colonic tumorigenesis; R.-D. Duan. Section V: Lifestyle Factors and CRC Risk. 17. Energy balance and obesity; R.W. Hart. 18. Physical activity and colorectal cancer: independent and interactive effects; M.L. Slattery. 19. Smoking and colorectal cancer; A. Chao, et al. 20. Bacteria in the pathogenesis of colorectal cancer; J.H. Cummings, G.T. Macfarlane. Section VI: Carcinogens and Co-Carcinogens. 21. The role of nitric oxide and oxygen radicals in colon carcinogenesis; S.R. Tannenbaum, D. Schauer. 22. The role of N-nitrosation in colon carcinogenesis: some recent insights; D.E.G. Shuker. 23. Heterocyclic aromatic amines; I.C. Roberts-Thomson. 24. Secondary bile acids; F.M. Nagengast. 25. Polyamines; V. Milovic, J. Stein. 26. Exocyclic DNA adducts derived from lipid peroxidation as oxidative stress markers in human colon carcinogenesis; H. Bartsch, J. Nair. Section VII: Protective Nutritional Factors. 27. Colon carcinogenesis: phytochemicals; H.K. Biesalski, et al. 28. Dietary fiber; M.E. Martinez. 29. Short chain fatty acids: the magic bullet? T. Menzel. 30. Flavonoids and their possible role in colon cancer prevention and therapy; U. Wenzel, H. Daniel. 31. Selenium in cancer prevention: optimization of selenoprotein expression or specific functions of selenium compounds? R. Brigelius-Flohé, et al. 32. Calcium: a protective agent against colorectal cancer? J.H. Kleibeuker, et al. Section VIII: Summary. 33. Dietary recommendations for prevention of colorectal cancer; R.S. Bresalier. 35. Cancer prevention: public health aspects; J.H. Weisburger. Index.