Autoimmunity

The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis eases and encompasses the actions of autoantibodies, autoantigeu-autoanti body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim mune disorders. The first six articles are generally concerned with the mech anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys tem, leading to a redirection of the immune response, would be therapeuti cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim munity, and the role of regulatory T cells. Further, an interesting phenome non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.

The Paradigms of Causality and Treatment for Autoimmune Disease. - Uncovering the Differences between T Cell Tolerance and Immunity. - The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: Generation, Specificity and Mode of Action. - Epitope Spreading: a Mechanism for Progression of Autoimmune Disease. - A Role for NF-? B and the Proteasome in Autoimmunity. - Complement Regulatory Proteins and Autoimmunity. - Pathogenic Immunity in Theiler s Virus-Induced Demyelinating Disease: a Viral Model for Multiple Sclerosis. - Evidence that Fas and FasL Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis. - The Role of Cytokines in Experimental Autoimmune Encephalomyelitis. - Involvement of Apoptotic Protease Cascade for Tissue Destruction in Sjögren s Syndrome. - Is Lack of Peripheral Tolerance Induction a Cause for Diabetes in the Non-Obese Diabetic Mouse? . - Neuro-Endocrine-Immune Axis in Human Rheumatoid Arthritis. - The Role of T Cells in Rheumatoid Arthritis.