Polymorphism in Pharmaceutical Solids

Using clear and practical examples, this volume presents a comprehensive examination of polymorphic behavior in pharmaceutical development. The book is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This second edition focuses on the pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics in this edition include computational methodologies, high-throughput screening methods, pharmaceutical cocrystals, and thermally-induced and solution-mediated phase transformations. The book also examines amorphous solids, the amorphous state, and crystallography preparation and characterization.

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

Topics include:

• Computational methodologies
• High-throughput screening methods
• Pharmaceutical cocrystals
• Thermally-induced and solution-mediated phase transformations
• Amorphous solids
• Crystallography preparation and characterization
• The amorphous state