Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
Inhaltsverzeichnis
Enzymes in Poly(ADP-Ribose) Metabolism. - PARP-2: Structure-Function Relationship. - Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals. - DNA Damage Signaling through Poly(ADP-Ribose). - Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity. - Functional Interactions of PARP-1 with p53. - Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1. - PARP-1 as Novel Coactivator of NF-? B in Inflammatory Disorders. - PARP and Epigenetic Regulation. - PARP and the Release of Apoptosis-Inducing Factor from Mitochondria. - Genome Degradation by DNAS1L3 Endonuclease. - NAD: Metabolism and Regulatory Functions. - PARP-1 and the Shape of Cell Death. - Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity. - Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury. - Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock. - Role of Poly-ADP-Ribosylation in Cancer Development. - PARP Inhibitors and Cancer Therapy. - Poly(ADP-Ribosyl)ation and Aging.