This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson's disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Inhaltsverzeichnis
Enzymes in Poly(ADP-Ribose) Metabolism. - PARP-2: Structure-Function Relationship. - Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals. - DNA Damage Signaling through Poly(ADP-Ribose). - Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity. - Functional Interactions of PARP-1 with p53. - Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1. - PARP-1 as Novel Coactivator of NF-? B in Inflammatory Disorders. - PARP and Epigenetic Regulation. - PARP and the Release of Apoptosis-Inducing Factor from Mitochondria. - Genome Degradation by DNAS1L3 Endonuclease. - NAD: Metabolism and Regulatory Functions. - PARP-1 and the Shape of Cell Death. - Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity. - Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury. - Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock. - Role of Poly-ADP-Ribosylation in Cancer Development. - PARP Inhibitors and Cancer Therapy. - Poly(ADP-Ribosyl)ation and Aging.